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Triglyceride containing lipid droplets and lipid droplet-associated proteins
Current Opinion in Lipidology, 2008Cytosolic lipid droplets are now recognized as dynamic organelles. This review summarizes our current understanding of the mechanisms involved in the formation of lipid droplets, the importance of lipid droplet-associated proteins and the link between lipid droplet accumulation and development of insulin resistance.Lipid droplets are formed as ...
Sven-Olof, Olofsson +6 more
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Microscopy, 2011
The lipid droplet (LD), an organelle that exists ubiquitously in various organisms, from bacteria to mammals, has attracted much attention from both medical and cell biology fields. The LD in white adipocytes is often treated as the prototype LD, but is rather a special example, considering that its size, intracellular localization and molecular ...
Michitaka, Suzuki +3 more
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The lipid droplet (LD), an organelle that exists ubiquitously in various organisms, from bacteria to mammals, has attracted much attention from both medical and cell biology fields. The LD in white adipocytes is often treated as the prototype LD, but is rather a special example, considering that its size, intracellular localization and molecular ...
Michitaka, Suzuki +3 more
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Phospholipids and lipid droplets
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013Lipid droplets are ubiquitous cellular organelles that allow cells to store large amounts of neutral lipids for membrane synthesis and energy supply in times of starvation. Compared to other cellular organelles, lipid droplets are structurally unique as they are made of a hydrophobic core of neutral lipids and are separated to the cytosol only by a ...
Anke, Penno +2 more
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Lipid Structure in Triolein Lipid Droplets
The Journal of Physical Chemistry B, 2014Lipid droplets (LDs) are primary repositories of esterified fatty acids and sterols in animal cells. These organelles originate on the lumenal or cytoplasmic side of endoplasmic reticulum (ER) membrane and are released to the cytosol. In contrast to other intracellular organelles, LDs are composed of a mass of hydrophobic lipid esters coved by ...
Chaban, Vitaly V, Khandelia, Himanshu
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Lipid droplets and cellular lipid flux [PDF]
Nature Cell BiologyLipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review the current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabolites at membrane contact sites, and the role of ...
Alyssa J. Mathiowetz, James A. Olzmann
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Adipocyte‐Derived Anticancer Lipid Droplets
Advanced Materials, 2021AbstractEngineering of efficient and safe materials remains a challenge for cancer therapy. Here, the lipid droplet, an organelle in adipocytes, is demonstrated to be a controllable and biocompatible vehicle to deliver anticancer drugs. It is validated that isolated lipid droplets maintain their key physiological functions to interact with other ...
Tingxizi Liang +10 more
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The New Face of the Lipid Droplet: Lipid Droplet Proteins
PROTEOMICS, 2018AbstractThe lipid droplet (LD) is an organelle with vital functions found in nearly all organisms. LD proteomic research has provided fundamentally important insights into this organelle's functions. The review provides a summary of LD proteomic studies conducted across diverse organisms and cell and tissue types.
Congyan, Zhang, Pingsheng, Liu
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Lipid Droplets and Neurodegeneration
NeuroscienceEnergy metabolism in the brain has been considered one of the critical research areas of neuroscience for ages. One of the most vital parts of brain metabolism cascades is lipid metabolism, and fatty acid plays a crucial role in this process. The fatty acid breakdown process in mitochondria undergoes through a conserved pathway known as β-oxidation ...
Keya Mallick +3 more
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DFCP1 associates with lipid droplets
Cell Biology International, 2019AbstractDouble FYVE‐containing protein 1 (DFCP1) is ubiquitously expressed, participates in intracellular membrane trafficking and labels omegasomes through specific interactions with phosphatidylinositol‐3‐phosphate (PI3P). Previous studies showed that subcellular DFCP1 proteins display multi‐organelle localization, including in the endoplasmic ...
Guangang, Gao +4 more
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Cytoskeleton regulates lipid droplet fusion and lipid storage by controlling lipid droplet movement
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsLipid droplets (LDs) are highly dynamic organelles that maintain cellular lipid homeostasis through size and number control. In adipose tissue, CIDEC plays a crucial role in LD fusion and lipid homeostasis. However, the regulatory factors and mechanisms of LD fusion remain largely unknown.
Yan, Liang +11 more
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