Results 101 to 110 of about 174,447 (304)

Lipid Droplets as Organelles [PDF]

, 2018
Long considered inert fat storage depots, it has become clear that lipid droplets (LDs) are bona fide organelles. Like other organelles, they have a characteristic complement of proteins and lipids, and undergo a life cycle that includes biogenesis, maturation, interactions with other organelles, and turnover.
openaire   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum

Journal of Lipid Research, 2001
A monoclonal antibody, ASH1a/256C (256C), which binds to atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbit (WHHL) aorta in vivo, recognizes complex structures of phosphatidylcholine mixed with neutral lipids.
Masahiro Mori, Hiroyuki Itabe, Yusuke Higashi, Yasuyuki Fujimoto, Masahiro Shiomi, Masao Yoshizumi, Yasuyoshi Ouchi, Tatsuya Takano   +7 more
doaj   +1 more source

Belousov-Zhabotinsky droplet mixing on-chip for chemical computing applications

, 2013
Without an imposed physical structure, even the most complex chemistries are limited in their ability to process information. For example, the Belousov-Zhabotinsky (BZ) oscillating reaction has been shown to have information procession potential, but ...
de Planque, Maurits R.R., Jones, Gareth, King, Philip H., Morgan, Hywel, Zauner, Klaus-Peter   +4 more
core  

Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue [PDF]

, 2007
In response to cold, norepinephrine (NE)-induced triacylglycerol hydrolysis (lipolysis) in adipocytes of brown adipose tissue (BAT) provides fatty acid substrates to mitochondria for heat generation (adaptive thermogenesis).
Bianco, Antonio C., Christoffolete, Marcelo A., D'Eon, Tara M., Greenberg, Andrew S., Imachi, Hitomi, Miyoshi, Hideaki, Obin, Martin S., Perfield, James W., II, Ribeiro, Miriam O., Rogers, Nicole H., Souza, Sandra C., Stancheva, Zlatina S., Strissel, Katherine J.   +12 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications [PDF]

, 2019
Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation and fibrillation makes ...
Alza, Natalia Paola, Conde, Melisa Ailén, Iglesias González, Pablo Andrés, Salvador, Gabriela Alejandra, Uranga, Romina Maria   +4 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization [PDF]

, 2016
Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals.
Bao, Yong P., Chen, Fen, Chen, Shi Y, Fu, Jian F, Shan, Yu J, Wang, An S, Yao, An J, Zhang, Hui Q, Zhang, Xiao H, Zhao, Jin S, Zhou, Zu Q   +10 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source