Results 161 to 170 of about 1,446,619 (399)

Porcine deltacoronavirus infection promotes intracellular lipid droplet accumulation

Virology Journal
Background Viruses critically depend on host lipid metabolism to drive replication, assembly and immune evasion during infection and pathogenesis. While previous studies have demonstrated that certain viruses induce lipid droplet accumulation in infected
Xiaohui Yang, Haiwen Zhong, Chuanzhao Yu, Jie Cheng, Huijie Jiang, Cuizhen Wang, Changxu Song, Huaqiang Yang   +7 more
doaj   +1 more source

Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis[S]

Journal of Lipid Research, 2013
We sought to determine whether hepatic cholesterol crystals are present in patients or mice with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NASH), and whether their presence or distribution correlates with the presence of NASH as ...
George N. Ioannou, W. Geoffrey Haigh, David Thorning, Christopher Savard   +3 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnovers⃞

Journal of Lipid Research, 2007
Although neutral lipid storage droplets are ubiquitous in eukaryotic cells, very little is known about how their synthesis and turnover are controlled. Adipocyte differentiation-related protein (ADRP; also known as adipophilin) is found on the surface of
Laura L. Listenberger, Anne G. Ostermeyer-Fay, Elysa B. Goldberg, William J. Brown, Deborah A. Brown   +4 more
doaj   +1 more source

Emulsion formation and stabilization by biomolecules: the leading role of cellulose [PDF]

, 2019
Emulsion stabilization by native cellulose has been mainly hampered because of its insolubility in water. Chemical modification is normally needed to obtain water-soluble cellulose derivatives.
Costa, C., Edlund, H., Filipe, Alexandra, Lindman, B., Medronho, Bruno, Mira, I., Norgren, M.   +6 more
core   +1 more source

Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Lipids have essential roles in cellular energy homeostasis and are key structural components of membranes and thereby provide the basis of cellular compartmentalization.
J. Mahamid, D. Tegunov, Andreas Maiser, Jan Arnold, H. Leonhardt, J. Plitzko, W. Baumeister   +6 more
semanticscholar   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans

Journal of Lipid Research, 2012
Lipid droplets are cellular organelles that consists of a neutral lipid core covered by a monolayer of phospholipids and many proteins. They are thought to function in the storage, transport, and metabolism of lipids, in signaling, and as a specialized ...
Li Yang, Yunfeng Ding, Yong Chen, Shuyan Zhang, Chaoxing Huo, Yang Wang, Jinhai Yu, Peng Zhang, Huimin Na, Huina Zhang, Yanbin Ma, Pingsheng Liu   +11 more
doaj   +1 more source

Ice Lithography: Recent Progress Opens a New Frontier of Opportunities

Advanced Functional Materials, EarlyView.
This review focuses on recent advancements in ice lithography, including breakthroughs in compatible precursors and substrates, processes and applications, hardware, and digital methods. Moreover, it offers a roadmap to uncover innovation opportunities for ice lithography in fields such as biological, nanoengineering and microsystems, biophysics and ...
Bingdong Chang, Gwendoline A. E. Anand, Rubaiyet Haque, Dylan A. Chiaro, Mona Sharma, Andrew R. Williams, Frank Niklaus, Daryl W. Yee, Gavin M. King, Anpan Han   +9 more
wiley   +1 more source

LRRK2 mediated Rab8a phosphorylation promotes lipid storage

Lipids in Health and Disease, 2018
Background Several mutations in leucine rich repeat kinase 2 (LRRK2) gene have been associated with pathogenesis of Parkinson’s disease (PD), a neurodegenerative disorder marked by resting tremors, and rigidity, leading to Postural instability.
Miao Yu, Muhammad Arshad, Wenmin Wang, Dongyu Zhao, Li Xu, Linkang Zhou   +5 more
doaj   +1 more source