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Lipid Droplets and Neurodegeneration
NeuroscienceEnergy metabolism in the brain has been considered one of the critical research areas of neuroscience for ages. One of the most vital parts of brain metabolism cascades is lipid metabolism, and fatty acid plays a crucial role in this process. The fatty acid breakdown process in mitochondria undergoes through a conserved pathway known as β-oxidation ...
Keya Mallick +3 more
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DFCP1 associates with lipid droplets
Cell Biology International, 2019AbstractDouble FYVE‐containing protein 1 (DFCP1) is ubiquitously expressed, participates in intracellular membrane trafficking and labels omegasomes through specific interactions with phosphatidylinositol‐3‐phosphate (PI3P). Previous studies showed that subcellular DFCP1 proteins display multi‐organelle localization, including in the endoplasmic ...
Guangang, Gao +4 more
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Cytoskeleton regulates lipid droplet fusion and lipid storage by controlling lipid droplet movement
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsLipid droplets (LDs) are highly dynamic organelles that maintain cellular lipid homeostasis through size and number control. In adipose tissue, CIDEC plays a crucial role in LD fusion and lipid homeostasis. However, the regulatory factors and mechanisms of LD fusion remain largely unknown.
Yan, Liang +11 more
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Lipid Droplets and Viral Infections
2013The lifecycle of several viruses is intimately tied to the lipid metabolism of their host cells, and lipid droplets (LDs) have emerged as crucial organelles in the propagation of these viral infections. Investigating the roles of LDs in viral infection requires expertise in both virology and cell metabolism pertaining to LDs.
Gregory, Camus +3 more
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Mechanisms of lipid droplet biogenesis
Biochemical Journal, 2019Abstract Lipid droplets (LDs) are organelles that compartmentalize nonbilayer-forming lipids in the aqueous cytoplasm of cells. They are ubiquitous in most organisms, including in animals, protists, plants and microorganisms. In eukaryotes, LDs are believed to be derived by a budding and scission process from the surface of the ...
Kent D. Chapman +3 more
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Mechanisms of lipid droplet degradation
Current Opinion in Cell BiologyLipid droplets (LDs) are subcellular organelles that play an integral role in lipid metabolism by regulating the storage and release of fatty acids, which are essential for energy production and various cellular processes. Lipolysis and lipophagy are the two major LD degradation pathways that mediate the utilization of lipids stored in these organelles.
Joshua H. Corbo, Jeeyun Chung
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Lipid droplets, lipophagy, and beyond
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2016Lipids are essential components for life. Their various structural and physical properties influence diverse cellular processes and, thereby, human health. Lipids are not genetically encoded but are synthesized and modified by complex metabolic pathways, supplying energy, membranes, signaling molecules, and hormones to affect growth, physiology, and ...
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Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases
Nature Reviews Molecular Cell Biology, 2023Shigekatzu Nagata
exaly