Results 71 to 80 of about 863,741 (256)

Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum

Journal of Lipid Research, 2001
A monoclonal antibody, ASH1a/256C (256C), which binds to atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbit (WHHL) aorta in vivo, recognizes complex structures of phosphatidylcholine mixed with neutral lipids.
Masahiro Mori, Hiroyuki Itabe, Yusuke Higashi, Yasuyuki Fujimoto, Masahiro Shiomi, Masao Yoshizumi, Yasuyoshi Ouchi, Tatsuya Takano   +7 more
doaj   +1 more source

CtBP1-S/BARS regulates Lipid Droplets biogenesis

, 2016
Lipid droplets (LDs) are intracellular lipid-storing organelles surrounded by a phospholipid monolayer. LDs emerge as metabolically active organelles involved in many biological processes and linked to the pathogenesis of several dysfunctions including ...
Valente C, Circolo D, Ikonen E, Luini A, Corda D, Filograna A   +5 more
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

LIPID DROPLETS AND NUCLEAR LIPID DYNAMICS

European Journal of Histochemistry
Lipid droplets (LDs) are present in the nucleus, though much less abundant than cytoplasmic LDs. We investigated nuclear LDs generated in amino acid-deprived conditions, and found that diacylglycerol (DAG), produced by ATGL-mediated hydrolysis of ...
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Lipid Droplets and the Pathophysiology of Liver Diseases

, 2019
Lipid droplets (LDs) are widespread intracellular organelles formed by a triglyceride, cholesteryl ester and retinyl ester core surrounded by a monolayer of phospholipids and free (unesterified) cholesterol.
Quiroga, Ariel Dario
core  

Functionalizing lipid sponge droplets with DNA**

, 2022
Nucleic acids are among the most versatile molecules for the construction of biomimetic systems because they can serve as information carriers and programmable construction materials.
Christy J. Cho, Cho, C., Niederholtmeyer, H., Seo, H., Hyeonglim Seo, Bhattacharya, A., Henrike Niederholtmeyer, Ahanjit Bhattacharya, Neal K. Devaraj, Devaraj, N.   +9 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

A ratiometric fluorescent probe monitoring lipid peroxidation within lipid droplets in foam cells

Smart Molecules
Lipid peroxidation (LPO) in foam cells is crucial for regulating atherosclerosis progression. It correlates with lipid uptake and the state of lipid droplets. In this study, we report a lipid droplet‐targeted fluorescent LPO probe, Ld‐LPO. It selectively
Dingxuan Li, Caiwei Lu, Shulan Sun, Xiaoxi Li, Yi Xiao, Xinfu Zhang   +5 more
doaj   +1 more source

Selective PCB accumulation in lipid droplets of isolated primary adipocytes.

, 2013
Primary adipocytes from cav-1 KO and WT mice were isolated by collagenase treatment and incubated during 2 h with a cocktail of PCB-s 28, -118 and -153 added at a concentration of 30 µM.
Sophie Bourez (329698), Isabelle Dugail (332425), Jean-Pierre Thomé (332424), Soazig Le Lay (332419), Yves-Jacques Schneider (329704), Carine Van den Daelen (332422), Cathy Debier (329703), Caroline Louis (332423), Yvan Larondelle (217999)   +8 more
core   +1 more source