Purple perilla extracts allay ER stress in lipid-laden macrophages. [PDF]
PLoS ONE, 2014 There is a growing body of evidence that excess lipids, hypoxic stress and other inflammatory signals can stimulate endoplasmic reticulum (ER) stress in metabolic diseases.
Sin-Hye Park +4 more
doaj +6 more sources
Lipid-Laden Macrophages Recycle Myelin to Feed Glioblastoma. [PDF]
Cancer ResTumor-associated microglia and macrophages (TAM) make up the largest immune cell population in the glioblastoma (GBM) tumor microenvironment. Given the heterogeneity and plasticity of TAMs in the GBM tumor microenvironment, understanding the context-dependent cancer cell–TAM symbiotic interaction is crucial for
Pang L, Zhou F, Chen P.
europepmc +3 more sources
Extracellular vesicles from ovarian cancer cells induce senescent lipid-laden macrophages to facilitate omental metastasis [PDF]
Journal of NanobiotechnologyBackground Ovarian cancer exhibits striking metastatic tropism for the omentum, where lipid-laden macrophages are key mediators that fuel disease progression.
Guoqing Li +13 more
doaj +2 more sources
Myelin debris uptake by macrophages and microglia: Resolution of foam cells with a series of novel cyclodextrins [PDF]
NeurotherapeuticsFoamy, lipid-laden macrophages are found in multiple sclerosis (MS) lesions, resulting from excessive phagocytosis of myelin debris following demyelination.
Emily C. Wuerch +7 more
doaj +2 more sources
Lipid-Laden alveolar macrophages and vaping: Lessons from EVALI [PDF]
EBioMedicine, 2020 Andrea Jonas
doaj +3 more sources
Lipid-Laden M1-like Macrophages of Familial Hypercholesterolemia Patients Are Characterized by Increased Interleukin-1β Secretion and Reduced TMEM176A and TMEM176B Gene Expression [PDF]
Current Issues in Molecular BiologyFamilial hypercholesterolemia (FH) is a common hereditary dyslipidemia characterized by high levels of low-density lipoprotein (LDL) cholesterol and a risk of premature atherosclerosis. Previous studies showed that cardiovascular risks persist in FH even
Artem Izyumchenko +12 more
doaj +2 more sources
The Hepatic Crown-like Structure: A Focal Point for Macrophage Evolution and Disease Response in Steatotic Liver Disease [PDF]
LiversThe hepatic crown-like structure (hCLS) is a shell-like aggregate of macrophages surrounding a large lipid-laden dying hepatocyte. This feature was initially assumed to simply be a response to increased inflammatory stress during steatotic liver disease,
Kyle Yuquimpo +3 more
doaj +2 more sources
Xanthomatous pleuritis in a child with recurrent pneumonia and patent ductus arteriosus: A rare pediatric case report and literature review [PDF]
Respiratory Medicine Case ReportsBackground: Xanthomatous pleuritis is an exceptionally rare benign inflammatory condition characterized by aggregates of lipid-laden macrophages within the pleura.
Seyedeh Zalfa Modarresi +4 more
doaj +2 more sources
Monocyte and macrophage foam cells in diabetes-accelerated atherosclerosis
Frontiers in Cardiovascular Medicine, 2023 Diabetes results in an increased risk of atherosclerotic cardiovascular disease. This minireview will discuss whether monocyte and macrophage lipid loading contribute to this increased risk, as monocytes and macrophages are critically involved in the ...
Jocelyn Cervantes, Jenny E. Kanter
doaj +1 more source
Current Issues in Molecular Biology, 2023 Atherosclerosis is driven by intimal arterial macrophages accumulating cholesterol. Atherosclerosis also predominantly occurs in areas consisting of proinflammatory arterial endothelial cells.
Jing Echesabal-Chen +8 more
doaj +1 more source