Results 21 to 30 of about 13,041 (236)
Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation
Nature Communications, 2023 Accumulation of lipid-laden macrophages within the arterial neointima is a critical step in atherosclerotic plaque formation. Here, we show that reduced levels of the cellular plasticity factor ZEB1 in macrophages increase atherosclerotic plaque ...
M. C. Martinez-Campanario +16 more
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The fat is in the lysosome: how Mycobacterium tuberculosis tricks macrophages into storing lipids
The Journal of Clinical Investigation, 2023 Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects primarily macrophages, causing them to differentiate into lipid-laden foamy macrophages that are a primary source of tissue destruction in patients with TB.
Yoann Rombouts, Olivier Neyrolles
doaj +1 more source
Xanthomatosis: An Insight to Familial Hypercholesterolemia [PDF]
National Journal of Laboratory Medicine, 2016 Familial hypercholesterolemia is a “RECEPTOR DISEASE” that is the consequence of a mutation in the gene encoding the receptor for low-density lipoprotein, which is involved in the transport and metabolism of cholesterol.
Jaya Manchanda +3 more
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Pulmonary Medicine, 2012 Lipid-laden alveolar macrophages and pH monitoring have been used in the diagnosis of chronic aspiration in children with gastroesophageal reflux (GER).
R. Kitz +3 more
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Shine like gold and sparkle like glitter: Three cases of lipoid pneumonia
Respiratory Medicine Case Reports, 2021 Lipoid pneumonia (LP) is an unwonted, mostly asymptomatic entity which has no classical radiological appearance. It can be endogenous or exogenous depending upon the type of exposure or underlying milieu.
Vishak Acharya +4 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2014 Aims: γ-aminobutyric acid (GABA), the principal inhibitory neurotransmitter, acts on GABA receptors to play an important role in the modulation of macrophage functions.
Ying Yang +5 more
doaj +1 more source
Journal of Mid-Life Health, 2023 Xanthogranulomatous inflammation, a specific form of chronic inflammation, is marked by parenchymal destruction, proliferative fibrosis, and infiltration of typical foamy histiocytes admixed with hemosiderin-laden macrophages and foreign-body giant cells.
Mukta Pujani +5 more
doaj +1 more source
A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages
The Journal of Clinical Investigation, 2023 Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche.
Melissa Bedard +22 more
doaj +1 more source
Lipid-laden macrophage index and inflammation in bronchoalveolar lavage fluids in children [PDF]
European Respiratory Journal, 2001 The presence of lipids in alveolar macrophages has been used clinically as an indicator of aspiration, a process associated with increased lung inflammation in animal models. The hypothesis is that the quantity of lipids in alveolar macrophages, measured as lipid-laden index (LLI), would correlate with lung inflammation in paediatric patients.Children ...
M Y, Kazachkov +3 more
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Lipid-laden macrophages in atherosclerosis and cancer
Seminars in Cancer BiologyThis review explores the dual roles of lipid-laden macrophages (LL-Macs) in inflammation, atherosclerosis and cancer, emphasizing both their shared and divergent functions across physiological and pathological conditions. Lipid metabolism regulates the polarization of macrophages in homeostasis and inflammation.
MC Martinez-Campanario +8 more
openaire +2 more sources