Results 111 to 120 of about 203,017 (297)

Mast cells as the strength of the inflammatory process

Polish Journal of Pathology, 2017
The inflammatory process is a complex host defence mechanism aimed at the elimination of deleterious factors disturbing homeostasis. Inflammation consists of several interdependent stages controlled by a wide range of mediators. Those include acute phase
Joanna Pastwińska, Justyna Agier, Jarosław Dastych, Ewa Brzezińska-Błaszczyk   +3 more
doaj   +1 more source

Lipids and Lipid-Mediated Signaling in Plant–Pathogen Interactions

International Journal of Molecular Sciences
Plant lipids are essential cell constituents with many structural, storage, signaling, and defensive functions. During plant–pathogen interactions, lipids play parts in both the preexisting passive defense mechanisms and the pathogen-induced immune responses at the local and systemic levels.
Elżbieta Kuźniak, Ewa Gajewska
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Plasma C16-Cer levels are increased in patients with preterm labor

, 2016
The pathogenesis of preterm labor is fragmentarily explained. The most widely accepted theory points out to infection and inflammation as possible causes, which can be mediated by potentially different factors, including sphingolipid mediators ...
Kuc, Pawel, Dymicka-Piekarska, Violetta, Blachnio-Zabielska, Agnieszka, Kisielewski, Rafal, Raba, Grzegorz, Charkiewicz, Karol, Jacobsson, Bo,, Laudanski, Piotr, Kacerovsky, Marian, Kraczkowski, Janusz, Koc-Zorawska, Ewa, Chabowski, Adrian, Zabielski, Piotr   +12 more
core   +1 more source

Omega-3 Polyunsaturated Fatty Acid Derived Lipid Mediators and Their Application in Drug Discovery.

, 2020
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play crucial and often opposing regulatory roles in health and in pathological conditions.
Pazderka, CW, Tristan Rawling, Murray, M, Curtis W. Pazderka, Rawling, T, Oliver, B, Brian Oliver, Michael Murray   +7 more
core   +1 more source

Arachidonic Acid Derived Lipid Mediators Influence Kaposi’s Sarcoma-Associated Herpesvirus Infection and Pathogenesis

Frontiers in Microbiology, 2019
Kaposi’s sarcoma-associated herpesvirus (KSHV) infection, particularly latent infection is often associated with inflammation. The arachidonic acid pathway, the home of several inflammation and resolution associated lipid mediators, is widely altered ...
Jayashree A. Chandrasekharan, Neelam Sharma-Walia   +1 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Targeting lipid mediators in asthma : time for reappraisal

, 2019
PURPOSE OF REVIEW: In the past decades, cysteinyl leukotrienes (CysLTs) and prostaglandin D2 have been recognized as key mediators of asthma and comorbid conditions for their potent broncho-active and proinflammatory properties.
Diamant, Zuzana, Zuzana Diamant, Wytze Aalders, Nicola A. Hanania, Hanania, Nicola A.,, Bjermer, Leif, Bjermer, Leif,, Amit Parulekar, Hanania, Nicola A., Aalders, Wytze,, Parulekar, Amit,, Parulekar, Amit, Leif Bjermer, Aalders, Wytze, Diamant, Zuzana,, Lund University.   +15 more
core   +1 more source

Air pollution and Alzheimer disease phenotype deplete esterified proresolving lipid mediator reserves in the brain

JCI Insight
BACKGROUND Traffic-related air pollution (TRAP) is a risk factor for Alzheimer disease (AD), where unresolved brain inflammation has been linked to deficits in the levels of free lipid mediators that enable the resolution of inflammation.
Ameer Y. Taha, Qing Shen, Yurika Otoki, Nuanyi Liang, Kelley T. Patten, Anthony E. Valenzuela, Christopher D. Wallis, Douglas J. Rowland, Abhijit J. Chaudhari, Keith J. Bein, Anthony S. Wexler, Lee-Way Jin, Brittany N. Dugger, Danielle J. Harvey, Pamela J. Lein   +14 more
doaj   +1 more source

In regards to lipoxins as lipid mediators for the resolution of inflammation using the example of asthma

Acta Biomedica Scientifica
Asthma is the most important medical and social problem of our time due to its widespread prevalence, chronic course and heterogeneity, which determines the complexity of  treating this disease.
O. Yu. Kytikova, T. P. Novgorodtseva, I. S. Kovalenko   +2 more
doaj   +1 more source