Results 91 to 100 of about 203,017 (297)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Mechanism of thromboxane receptor-induced vasoconstriction in human saphenous vein
, 2021 Saphenous vein (SV) is one of the most widely used graft material in patients undergoing coronary artery bypass graft surgery (CABG). Thromboxane A(2) (TXA(2)) is implicated in graft failure by inducing vasoconstriction and platelet aggregation.
Turkyılmaz, G +7 more
core +1 more source
Vesicular trafficking and signaling for cytokine and chemokine secretion in mast cells
Frontiers in Immunology, 2014 Upon activation mast cells (MC) secrete numerous inflammatory compounds stored in their cytoplasmic secretory granules (SG) by a process called anaphylactic degranulation, which is responsible for type I hypersensitivity responses.
Ulrich eBlank +19 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
, 2018 Although oxylipins are involved in inflammation, data on these lipid mediators in multiple sclerosis are sparse. In this study, a panel of oxylipins were analysed swith liquid chromatography tandem mass spectrometry in cerebrospinal fluid (CSF) from 41 ...
Nording, Malin, +8 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Dietary extra virgin olive oil down regulates oxidized lipid mediators in CCl4 induced liver injury
, 2013 Dietary oils rich in unsaturated fatty acids demonstrate various effects in chronic liver injury. Some reports indicated that extra virgin olive oil has better benefits against carbon tetrachloride (CCl4) induced liver injury, but the details are still ...
Wang, H +4 more
core
Mediadores químicos e resposta celular na colite induzida pelo DSS: papel dos mediadores lipídicos derivados do omega-3 na resolução da colite experimental [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaAs doenças inflamatórias intestinais (IBD) representam um grupo de disfunções do trato gastrointestinal, que acometem ...
Bento, Allisson Freire
core
Endogenous Receptor Agonists: Resolving Inflammation
The Scientific World Journal, 2007 Controlled resolution or the physiologic resolution of a well-orchestrated inflammatory response at the tissue level is essential to return to homeostasis. A comprehensive understanding of the cellular and molecular events that control the termination of
Gerhard Bannenberg +2 more
doaj +1 more source