Results 71 to 80 of about 328,980 (298)

Resolution of inflammation: Therapeutic potential of pro-resolving lipids in Type 2 diabetes mellitus and associated renal complications

Frontiers in Immunology, 2012
The role of inflammation in the pathogenesis of type 2 diabetes mellitus (T2DM) and its associated complications is increasingly recognized. The resolution of inflammation is actively regulated by endogenously produced lipid mediators such as lipoxins ...
Emma eBorgeson, Catherine eGodson
doaj   +1 more source

Lipid mediators in immune regulation and resolution [PDF]

British Journal of Pharmacology, 2019
We are all too familiar with the events that follow a bee sting—heat, redness, swelling, and pain. These are Celsus' four cardinal signs of inflammation that are driven by very well‐defined signals and hormones. In fact, targeting the factors that drive this onset phase is the basis upon which most current anti‐inflammatory therapies were developed. We
Derek W. Gilroy, David Bishop‐Bailey
openaire   +4 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Apolipoprotein E related Co-Morbidities and Alzheimer’s disease [PDF]

, 2016
The primary goal of advancement in clinical services is to provide a health care system that enhances an individual’s quality of life. Incidence of diabetes mellitus, cardiovascular disease and associated dementia coupled with the advancing age of the ...
Akiyama, Alharbi, Armitage, Armitage, Armitage, Balin, Barbieri, Bergdahl, Berliner, Borilova Linhartova, Borrell-Pages, Bowling, Braak, Braak, Brown, Bu, Buchanan, Burt, Cambell, Cavrini, Chiu, Chukkapalli, Chukkapalli, Chukkapalli, Cole, Corder, Corrada, Curtiss, Cutler, De Oliveira, DeFronzo, DeStefano, Desvarieux, Duarte, Epel, Farrer, Forner, Foster, Freitag-Wolf, Galbraith, Gan, Gao, Genco, Grehan, Grossi, Habib, Haffajee, Hajishengalis, Hajishengalis, Haraszthy, Hardardottir, Hardy, Harold, Harper, Hayashi, Hayden, Heiduschka, Helfand, Het, Hitt, Holt, Hu, Huang, Hunter, Hutton, Imhof, Iqbal, Itzhaki, Jagannathachary, Joiner, Kamer, Kamer, Kamer, Katz, Khovidhunkit, Klein, Kliegel, Kolovou, Kornman, Kozarov, Kubota, Lalla, Lambert, Lesne, Leszcynska, Libby, Machado, Mahley, Mahley, Mahley, Mahley, Maney, Marti, McGeer, Michalowicz, Miklossy, Miklossy, Miller, Mooradian, Moutsopoulos, Nagpal, Neto, Nicoll, Noble, Okuda, Olsen, Ono, O’Brien, Papapanou, Perls, Pitas, Pizzo, Poirier, Poling, Poole, Poole, Rivera, Riviere, Rogers, Rohn, Roses, Roses, Rowe, Saito, Saunders, Scannapieco, Schuett, Shao, Singhrao, Singhrao, Singhrao, Singhrao, Small, Smit, Socransky, Soscia, Stein, Strittmatter, Strittmatter, Sullivan, Velsko, Walsh, Walsh, Watkins, Weisgraber, Wetterau, Wilson, Young   +147 more
core   +1 more source

A mitochondrial pathway for biosynthesis of lipid mediators [PDF]

Nature Chemistry, 2014
The central role of mitochondria in metabolic pathways and in cell-death mechanisms requires sophisticated signalling systems. Essential in this signalling process is an array of lipid mediators derived from polyunsaturated fatty acids. However, the molecular machinery for the production of oxygenated polyunsaturated fatty acids is localized in the ...
Tyurina, Yulia Y., Poloyac, Samuel M., Tyurin, Vladimir A., Kapralov, Alexander A., Jiang, Jianfei, Anthonymuthu, Tamil Selvan, Kapralova, Valentina I., Vikulina, Anna S., Jung, Mi-Yeon, Epperly, Michael W., Mohammadyani, Dariush, Klein-Seetharaman, Judith, Jackson, Travis C., Kochanek, Patrick M., Pitt, Bruce R., Greenberger, Joel S., Vladimirov, Yury A., Bayır, Hülya, Kagan, Valerian E.   +18 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Temperature and time-dependent effects of delayed blood processing on oxylipin concentrations in human plasma. [PDF]

, 2019
BACKGROUND:Oxidized derivatives of polyunsaturated fatty acids, collectively known as oxylipins, are labile bioactive mediators with diverse roles in human physiology and pathology.
Gibson, Robert A, Horowitz, Mark S, Majchrzak-Hong, Sharon F, Makrides, Maria, Muhlhausler, Beverly S, Ramsden, Christopher E, Taha, Ameer Y, Yuan, Zhi-Xin, Zamora, Daisy   +8 more
core   +1 more source

Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases [PDF]

, 2020
Prospective observational studies support the use of long-chain omega-3 polyunsaturated fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; however, randomised controlled trials, have often reported neutral findings ...
Abdelhamid, Abdelhamid, Al-Hilal, Allayee, Armstrong, Aung, Baylin, Bhatt, Bjermo, Bosch, Bowman, Brown, Burdge, Burr, Cannon, Chavez, Cho, Chowdhury, Colazzo, Contreras, Cormier, Das, Dayton, de Toro-Martin, Demetz, Dorris, Draisma, Dumont, Dumont, Dupuis, Dwyer, Farvid, Fezeu, Floegel, Floegel, Forouhi, Frantz, Fretts, Fumagalli, Gabbs, Gammelmark, Gammelmark, Gillingham, Gol, Gromovsky, Guan, Hamley, Harris, Harris, Harris, Heemskerk, Hellstrand, Hilvo, Hooper, Hu, Illig, Imamura, Innes, Jakobsen, Jamieson, Johnson, Juan, Jäger, Jäger, Keaney, Kemp, Kromhout, Kröger, Kröger, Lankinen, Lemaitre, Leren, Li, Ligthart, Liu, Lu, Mahajan, Maki, Manson, Marklund, Marklund, McManus, Micha, Miettinen, Moltó-Puigmartí, Monk, Monteiro, Mozaffarian, Mozaffarian, Mozaffarian, Nelson, Nicholls, O'Neill, Pan, Piepoli, Powell, Ramsden, Ramsden, Ramsden, Ratnayake, Rimm, Risérus, Rizos, Roncaglioni, Rosqvist, Ross, Sarwar, Serhan, Simopoulos, Sioen, Siscovick, Skeaff, Skulas-Ray, Smith, Standl, Stephensen, Stoffel, Sudmant, Sun, Takkunen, Trumbo, Turpeinen, Wang, Wang, Wei, White, Willer, Woodhill, Wu, Wu, Wu, Xue, Yamagishi, Ye, Yokoyama, Yuan, Zhang   +136 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source