Results 51 to 60 of about 194,410 (258)
Frontiers in Immunology, 2020 Polyunsaturated fatty acid-derived specialized pro-resolving lipid mediators (SPMs) play an important role in modulating inflammation. The aim of the study was to compare profiles of SPMs, SPM related lipid mediators and SPM receptor gene expression in ...
Brittney Ferguson +11 more
doaj +1 more source
Scientific Reports, 2022 Various fatty acyl lipid mediators are derived from dietary polyunsaturated fatty acids (PUFAs) and modulate nociception. The modern diet is rich in linoleic acid, which is associated with nociceptive hypersensitivities and may present a risk factor for ...
Nada Birkic +4 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Essential fatty acids and lipid mediators. Endocannabinoids
La Pediatria Medica e Chirurgica, 2012 In 1929 Burr and Burr discovered the essential fatty acids omega-6 and omega-3. Since then, researchers have shown a growing interest in polyunsaturated fatty acids (PUFA) as precursors of “lipid mediator” molecules, often with opposing effects ...
G. Caramia
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Lipid signaling in CD95‐mediated apoptosis [PDF]
FEBS Letters, 1999 Ceramides play an important role mediating different cell responses such as proliferation, differentiation, growth arrest and apoptosis. They are released upon sphingomyelin hydrolysis which occurs after triggering of a number of cell surface receptors including CD95. Ceramide generation also regulates glycosphingolipid and ganglioside metabolism.
MALISAN, FLORENCE, TESTI, ROBERTO
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Bioactive lipid mediators in polycystic kidney disease
Journal of Lipid Research, 2014 Inflammatory activity is evident in patients with chronic kidney disease with limited data available in autosomal dominant polycystic kidney disease (ADPKD). We hypothesized that inflammation is an upstream event in the pathogenesis of ADPKD and may be a
Jelena Klawitter +10 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A twist of FATe: Lipid droplets and inflammatory lipid mediators
Biochimie, 2020 Lipid droplets are fat storage organelles present in most eukaryotic cells. They consist of a neutral lipid core containing mostly triglycerides and sterol esters and covered by a monolayer of phospholipids, wherein numerous proteins are embedded. In the cell, lipid droplets have a dynamic life cycle, rapidly altering their size, location, lipid and ...
Eva Jarc, Toni Petan
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Lipid mediators in immune regulation and resolution [PDF]
British Journal of Pharmacology, 2019 We are all too familiar with the events that follow a bee sting—heat, redness, swelling, and pain. These are Celsus' four cardinal signs of inflammation that are driven by very well‐defined signals and hormones. In fact, targeting the factors that drive this onset phase is the basis upon which most current anti‐inflammatory therapies were developed. We
Derek W. Gilroy, David Bishop‐Bailey
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