Results 51 to 60 of about 324,910 (305)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Distinct Profiles of Specialized Pro-resolving Lipid Mediators and Corresponding Receptor Gene Expression in Periodontal Inflammation

Frontiers in Immunology, 2020
Polyunsaturated fatty acid-derived specialized pro-resolving lipid mediators (SPMs) play an important role in modulating inflammation. The aim of the study was to compare profiles of SPMs, SPM related lipid mediators and SPM receptor gene expression in ...
Brittney Ferguson, Nishantha R. Bokka, Krishna Rao Maddipati, Srinivas Ayilavarapu, Robin Weltman, Lisha Zhu, Wanqi Chen, W. Jim Zheng, Nikola Angelov, Thomas E. Van Dyke, Thomas E. Van Dyke, Chun-Teh Lee   +11 more
doaj   +1 more source

Excessive dietary linoleic acid promotes plasma accumulation of pronociceptive fatty acyl lipid mediators

Scientific Reports, 2022
Various fatty acyl lipid mediators are derived from dietary polyunsaturated fatty acids (PUFAs) and modulate nociception. The modern diet is rich in linoleic acid, which is associated with nociceptive hypersensitivities and may present a risk factor for ...
Nada Birkic, Toni Azar, Krishna Rao Maddipati, Zeljka Minic, Christian A. Reynolds   +4 more
doaj   +1 more source

The effect of melatonin on bacterial translocation following ischemia/reperfusion injury in a rat model of superior mesenteric artery occlusion [PDF]

, 2015
Background: Acute mesenteric ischemia is a life-threatening vascular emergency resulting in tissue destruction due to ischemia-reperfusion injury. Melatonin, the primary hormone of the pineal gland, is a powerful scavenger of reactive oxygen species (ROS)
Aydin, B., Aydin, C., Berber, I., Birsen, O., Cevahir, N., Gumrukcu, G., Yenisey, C., Özban, Murat.   +7 more
core   +2 more sources

Mast cells: from lipid droplets to lipid mediators [PDF]

Clinical Science, 2013
LDs (lipid droplets) are metabolically highly active intracellular organelles. The lipid and protein profiles of LDs are cell-type-specific, and they undergo dynamic variation upon changes in the physiological state of a cell. It is well known that the main function of the LDs in adipocytes is to ensure energy supply and to maintain lipid homoeostasis ...
Dichlberger, Andrea, Kovanen, Petri T., Schneider, Wolfgang J.   +2 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Essential fatty acids and lipid mediators. Endocannabinoids

La Pediatria Medica e Chirurgica, 2012
In 1929 Burr and Burr discovered the essential fatty acids omega-6 and omega-3. Since then, researchers have shown a growing interest in polyunsaturated fatty acids (PUFA) as precursors of “lipid mediator” molecules, often with opposing effects ...
G. Caramia
doaj   +1 more source

Temperature and time-dependent effects of delayed blood processing on oxylipin concentrations in human plasma. [PDF]

, 2019
BACKGROUND:Oxidized derivatives of polyunsaturated fatty acids, collectively known as oxylipins, are labile bioactive mediators with diverse roles in human physiology and pathology.
Gibson, Robert A, Horowitz, Mark S, Majchrzak-Hong, Sharon F, Makrides, Maria, Muhlhausler, Beverly S, Ramsden, Christopher E, Taha, Ameer Y, Yuan, Zhi-Xin, Zamora, Daisy   +8 more
core   +1 more source

Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid-Anchored Proteins [PDF]

Cell, 2015
Understanding how functional lipid domains in live cell membranes are generated has posed a challenge. Here, we show that transbilayer interactions are necessary for the generation of cholesterol-dependent nanoclusters of GPI-anchored proteins mediated by membrane-adjacent dynamic actin filaments.
Raghupathy, Riya, Anilkumar, Anupama Ambika, Polley, Anirban, Singh, Parvinder Pal, Yadav, Mahipal, Johnson, Charles, Suryawanshi, Sharad, Saikam, Varma, Sawant, Sanghapal D., Panda, Aniruddha, Guo, Zhongwu, Vishwakarma, Ram A., Rao, Madan, Mayor, Satyajit   +13 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source