Results 1 to 10 of about 1,243,207 (207)
Atomistic-Level Structural Insight into Vespa Venom (Ves a 1) and Lipid Membrane Through the View of Molecular Dynamics Simulation [PDF]
ToxinsThis study used all-atom molecular dynamics simulations to investigate the structural dynamics of Ves a 1, a phospholipase from Vespa affinis venom, and its interactions within a lipid membrane environment, both alone and in the presence of the inhibitor
Nawanwat Chainuwong Pattaranggoon +5 more
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Cells, 2023 Astrocytes are critical players in brain health and disease. Brain pathologies and lesions are usually accompanied by astroglial alterations known as reactive astrogliosis.
Shah Alam +6 more
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Sphingosine‐1‐phosphate‐lyase deficiency affects glucose metabolism in a way that abets oncogenesis
Molecular Oncology, 2022 Sphingosine‐1‐phosphate (S1P), a bioactive signaling lipid, is involved in several vital processes, including cellular proliferation, survival and migration, as well as neovascularization and inflammation.
Sumaiya Y. Afsar +3 more
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Molecular Oncology, 2021 Cancer development is a multistep process in which cells must overcome a series of obstacles before they can become fully developed tumors. First, cells must develop the ability to proliferate unchecked.
Antonia Piazzesi +2 more
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Lipid and Lipidation in Membrane Fusion
The Journal of Membrane Biology, 2022 Membrane fusion plays a lead role in the transport of vesicles, neurotransmission, mitochondrial dynamics, and viral infection. There are fusion proteins that catalyze and regulate the fusion. Interestingly, various types of fusion proteins are present in nature and they possess diverse mechanisms of action.
Avijit Sardar +4 more
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Spiroplasma membrane lipids [PDF]
Journal of Bacteriology, 1985 Membranes of six spiroplasma strains belonging to different Spiroplasma species and subgroups were isolated by a combination of osmotic lysis and sonication in the presence of EDTA to block endogenous phospholipase activity. Analysis of membrane lipids showed that in addition to free and esterified cholesterol the spiroplasmas incorporated exogenous ...
P J, Davis +3 more
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Cells, 2020 We have shown that sphingosine 1-phosphate (S1P) generated by sphingosine kinase 2 (SK2) is toxic in neurons lacking S1P-lyase (SGPL1), the enzyme that catalyzes its irreversible cleavage.
Shah Alam +4 more
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Membrane curvature sorts lipids [PDF]
EMBO reports, 2005 The enrichment of sphingolipids and cholesterol in the mammalian plasma membrane, and unsaturated phosphatidylcholine (PC) in the endoplasmic reticulum, requires lipid sorting in the Golgi apparatus. Most sphingolipids are synthesized in the Golgi lumen (Holthuis & Levine, 2005).
van Meer, G., Vaz, W.L.C.
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Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism
Nature Communications, 2023 Phospholipase D3 (PLD3) polymorphisms are linked to late-onset Alzheimer’s disease (LOAD). Being a lysosomal 5’-3’ exonuclease, its neuronal substrates remained unknown as well as how a defective lysosomal nucleotide catabolism connects to AD ...
Zoë P. Van Acker +11 more
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Nature Communications, 2022 Oxidized lipids are prominent bioactive agents, and yet their molecular repertoire remains largely unknown. Here, the authors apply bioinformatics and LC-MS/MS to uncover the diversity and specificity of modified lipids in human blood plasma of lean and ...
Angela Criscuolo +9 more
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