Results 11 to 20 of about 1,237,091 (306)

Analytical and computational workflow for in-depth analysis of oxidized complex lipids in blood plasma

open access: yesNature Communications, 2022
Oxidized lipids are prominent bioactive agents, and yet their molecular repertoire remains largely unknown. Here, the authors apply bioinformatics and LC-MS/MS to uncover the diversity and specificity of modified lipids in human blood plasma of lean and ...
Angela Criscuolo   +9 more
doaj   +1 more source

Phospholipid Preparations to Characterize Protein–Lipid Interactions In Vitro

open access: yesBio-Protocol, 2023
The lipid bilayers of the cell are composed of various lipid classes and species. These engage in cell signaling and regulation by recruiting cytosolic proteins to the membrane and interacting with membrane-embedded proteins to alternate their activity ...
Lisa Merklinger, Jens Morth
doaj   +1 more source

A Brief Introduction to Some Aspects of the Fluid–Mosaic Model of Cell Membrane Structure and Its Importance in Membrane Lipid Replacement

open access: yesMembranes, 2021
Early cell membrane models placed most proteins external to lipid bilayers in trimolecular structures or as modular lipoprotein units. These thermodynamically untenable structures did not allow lipid lateral movements independent of membrane proteins ...
Garth L. Nicolson   +1 more
doaj   +1 more source

Microcavity supported lipid membranes: versatile platforms for building asymmetric lipid bilayers and for protein recognition [PDF]

open access: yes, 2019
Microcavity supported lipid bilayers (MSLB) are contact-free membranes suspended across aqueousfilled pores that maintain the lipid bilayer in a highly fluidic state and free from frictional interactions with substrate.
Berselli, Guilherme   +4 more
core   +1 more source

Special Issue on “Sphingolipids: From Pathology to Therapeutic Perspectives”

open access: yesCells, 2020
It is an honor for us to dedicate this Special Issue to our dearest friend Lina Obeid, who was not only a pioneer in the field of sphingolipids, but also a remarkable personality [...]
Gerhild van Echten-Deckert
doaj   +1 more source

Membrane lipids and their degradation compounds control GM2 catabolism at intralysosomal luminal vesicles

open access: yesJournal of Lipid Research, 2019
The catabolism of ganglioside GM2 is dependent on three gene products. Mutations in any of these genes result in a different type of GM2 gangliosidosis (Tay-Sachs disease, Sandhoff disease, and the B1 and AB variants of GM2 gangliosidosis), with GM2 as ...
Susi Anheuser   +2 more
doaj   +1 more source

Lipids and membranes [PDF]

open access: yesFEBS Letters, 1974
Today, as in 1964, those who are concerned with membranes are broadly divided into two main groups: investigators who work on lipids and others who study proteins. Whether one pursues mainly this aspect or that is often more the result of individual interest and background rather than the outcome of a decision that one particular aspect of membranes is
openaire   +2 more sources

Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity[S]

open access: yesJournal of Lipid Research, 2015
Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease. It also accumulates in Niemann-Pick disease types A and B with primary storage of SM and with cholesterol in type C.
Susi Anheuser   +3 more
doaj   +1 more source

When Is a Reaction Network a Metabolism? Criteria for Simple Metabolisms That Support Growth and Division of Protocells

open access: yesLife, 2021
With the aim of better understanding the nature of metabolism in the first cells and the relationship between the origin of life and the origin of metabolism, we propose three criteria that a chemical reaction system must satisfy in order to constitute a
Paul G. Higgs
doaj   +1 more source

Onsager’s variational principle in soft matter : introduction and application to the dynamics of adsorption of proteins onto fluid membranes [PDF]

open access: yes, 2018
This book is the first collection of lipid-membrane research conducted by leading mechanicians and experts in continuum mechanics. It brings the overall intellectual framework afforded by modern continuum mechanics to bear on a host of challenging ...
Arroyo Balaguer, Marino   +3 more
core   +2 more sources

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