Results 11 to 20 of about 4,092,639 (351)
Lipid21: Complex Lipid Membrane Simulations with AMBER
Journal of Chemical Theory and Computation, 2022 We extend the modular AMBER lipid force field to include anionic lipids, polyunsaturated fatty acid (PUFA) lipids, and sphingomyelin, allowing the simulation of realistic cell membrane lipid compositions, including raft-like domains.
Callum J. Dickson, R. Walker, I. Gould
semanticscholar +1 more source
Distinct lipid membrane interaction and uptake of differentially charged nanoplastics in bacteria
Journal of Nanobiotechnology, 2022 Background Nanoplastics have been recently found widely distributed in our natural environment where ubiquitously bacteria are major participants in various material cycles. Understanding how nanoplastics interact with bacterial cell membrane is critical
Shang Dai +10 more
semanticscholar +1 more source
Interaction With the Lipid Membrane Influences Fentanyl Pharmacology
Advances in Drug and Alcohol Research, 2022 Overdose deaths from fentanyl have reached epidemic proportions in the USA and are increasing worldwide. Fentanyl is a potent opioid agonist that is less well reversed by naloxone than morphine.
K. Sutcliffe +10 more
semanticscholar +1 more source
LiPyphilic: A Python toolkit for the analysis of lipid membrane simulations
bioRxiv, 2021 Molecular dynamics simulations are now widely used to study emergent phenomena in lipid membranes with complex compositions. Here, we present LiPyphilic - a fast, fully tested, and easy to install Python package for analysing such simulations.
Paul E. Smith, C. Lorenz
semanticscholar +1 more source
Structure of a D2 dopamine receptor-G protein complex in a lipid membrane
Nature, 2020 The D2 dopamine receptor (DRD2) is a therapeutic target for Parkinson’s disease 1 and antipsychotic drugs 2 . DRD2 is activated by the endogenous neurotransmitter dopamine and synthetic agonist drugs such as bromocriptine 3 , leading to stimulation of G ...
Jie Yin +8 more
semanticscholar +1 more source
Biomimetics, 2020 Cell membranes are very complex biological systems including a large variety of lipids and proteins. Therefore, they are difficult to extract and directly investigate with biophysical methods.
A. Luchini, G. Vitiello
semanticscholar +1 more source
Phospholipid Preparations to Characterize Protein–Lipid Interactions In Vitro
Bio-Protocol, 2023 The lipid bilayers of the cell are composed of various lipid classes and species. These engage in cell signaling and regulation by recruiting cytosolic proteins to the membrane and interacting with membrane-embedded proteins to alternate their activity ...
Lisa Merklinger, Jens Morth
doaj +1 more source
Membranes, 2021 Early cell membrane models placed most proteins external to lipid bilayers in trimolecular structures or as modular lipoprotein units. These thermodynamically untenable structures did not allow lipid lateral movements independent of membrane proteins ...
Garth L. Nicolson +1 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 The autophagy protein ATG2, proposed to transfer bulk lipid from the endoplasmic reticulum (ER) during autophagosome biogenesis, interacts with ER residents TMEM41B and VMP1 and with ATG9, in Golgi-derived vesicles that initiate autophagosome formation ...
A. Ghanbarpour +3 more
semanticscholar +1 more source
Microcavity supported lipid membranes: versatile platforms for building asymmetric lipid bilayers and for protein recognition [PDF]
, 2019 Microcavity supported lipid bilayers (MSLB) are contact-free membranes suspended across aqueousfilled pores that maintain the lipid bilayer in a highly fluidic state and free from frictional interactions with substrate.
Berselli, Guilherme +4 more
core +1 more source