Results 21 to 30 of about 1,237,091 (306)

Partial synthesis of ganglioside and lysoganglioside lipoforms as internal standards for MS quantification

Journal of Lipid Research, 2014
Within recent years, ganglioside patterns have been increasingly analyzed by MS. However, internal standards for calibration are only available for gangliosides GM1, GM2, and GM3.
Martin Gantner, Günter Schwarzmann, Konrad Sandhoff, Thomas Kolter   +3 more
doaj   +1 more source

Physical Concept to Explain the Regulation of Lipid Membrane Phase Separation under Isothermal Conditions

Life, 2023
Lateral phase separation within lipid bilayer membranes has attracted considerable attention in the fields of biophysics and cell biology. Living cells organize laterally segregated compartments, such as raft domains in an ordered phase, and regulate ...
Naofumi Shimokawa, Tsutomu Hamada
doaj   +1 more source

Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase

Journal of Lipid Research, 2017
Glucosylceramide (GlcCer) is the primary storage lipid in the lysosomes of Gaucher patients and a secondary one in Niemann-Pick disease types A, B, and C.
Misbaudeen Abdul-Hammed, Bernadette Breiden, Günter Schwarzmann, Konrad Sandhoff   +3 more
doaj   +1 more source

Lateral phase separation in mixtures of lipids and cholesterol [PDF]

, 2004
In an effort to understand "rafts" in biological membranes, we propose phenomenological models for saturated and unsaturated lipid mixtures, and lipid-cholesterol mixtures.
Bloom M., D Andelman, Dietrich C., Feigenson G. W., H Shirotori, Kessel A., Lawrence J. C., Lipowsky R., Lipowsky R., Nielsen M., P. D Olmsted, Pandit S. A., Priest R. G., S Komura, Sackmann E., Veatch S. L., Yuan C.   +16 more
core   +2 more sources

Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2[S]

Journal of Lipid Research, 2014
During endocytosis, membrane components move to intraluminal vesicles of the endolysosomal compartment for digestion. At the late endosomes, cholesterol is sorted out mainly by two sterol-binding proteins, Niemann-Pick protein type C (NPC)1 and NPC2.
Vincent O. Oninla, Bernadette Breiden, Jonathan O. Babalola, Konrad Sandhoff   +3 more
doaj   +1 more source

Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development

Molecules, 2021
Plasmon waveguide resonance (PWR) is a variant of surface plasmon resonance (SPR) that was invented about two decades ago at the University of Arizona.
Estelle Rascol, Sandrine Villette, Etienne Harté, Isabel D. Alves   +3 more
doaj   +1 more source

Membrane-spanning lipids for an uncompromised monitoring of membrane fusion and intermembrane lipid transfer

Journal of Lipid Research, 2015
A Förster resonance energy transfer-based fusion and transfer assay was developed to study, in model membranes, protein-mediated membrane fusion and intermembrane lipid transfer of fluorescent sphingolipid analogs.
Günter Schwarzmann, Bernadette Breiden, Konrad Sandhoff   +2 more
doaj   +1 more source

Coupling between pore formation and phase separation in charged lipid membranes [PDF]

, 2015
We investigated the effect of charge on the membrane morphology of giant unilamellar vesicles (GUVs) composed of various mixtures containing charged lipids.
Hamada, Tsutomu, Higuchi, Yuji, Himeno, Hiroki, Ito, Hiroaki, Shimokawa, Naofumi, Takagi, Masahiro   +5 more
core   +2 more sources

Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes

Journal of Lipid Research, 2012
Phosphoinositides (PI) play important regulatory roles in cell physiology. Localization and quantitation of PIs within the cell is necessary to understand their precise function.
Yasuhiro Irino, Emi Tokuda, Junya Hasegawa, Toshiki Itoh, Tadaomi Takenawa   +4 more
doaj   +1 more source

Hydrophobic Mismatch Controls the Mode of Membrane-Mediated Interactions of Transmembrane Peptides

Membranes, 2022
Various cellular processes require the concerted cooperative action of proteins. The possibility for such synchronization implies the occurrence of specific long-range interactions between the involved protein participants.
Oleg V. Kondrashov, Peter I. Kuzmin, Sergey A. Akimov   +2 more
doaj   +1 more source