Results 81 to 90 of about 3,232,425 (402)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Dietary soy and meat proteins induce distinct physiological and gene expression changes in rats [PDF]

, 2016
This study reports on a comprehensive comparison of the effects of soy and meat proteins given at the recommended level on physiological markers of metabolic syndrome and the hepatic transcriptome.
A Hagiwara, A Lass, A Shukla, A Subramanian, AM Uhe, B He, BB Albert, C Brandsch, C Chaveroux, CJ Andersen, CW Law, D Eberle, D El Khoury, D Gaidatzis, D Karolchik, D Merico, D Ord, D Tome, DW Gietzen, E Tornberg, G Fromentin, G Sarwar, H Sidransky, HX Yuan, J Cacho, J Schwarz, JI Lee, JL Jewell, JM Beasley, KK Carroll, L Abatangelo, L Noriega-Lopez, LE Matarese, M Friedman, M Shimobayashi, MD Robinson, MD Robinson, ME Ritchie, ML Orgeron, MS Kilberg, N Tachibana, PG Reeves, PM Leung, PM Pereira, R Bourgon, R Hoffenberg, R Hosomi, S Guo, S Madani, S Wen, SM Potter, SN Twigger, T Berry, TG Anthony, V Ranawana, W Gade, W Kang, Y Takahashi   +57 more
core   +2 more sources

TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis

Nature Communications, 2023
Mitochondrial morphology, which is controlled by mitochondrial fission and fusion, is an important regulator of the thermogenic capacity of brown adipocytes.
Donghua Hu, Min Tan, Dongliang Lu, Brian Kleiboeker, Xuejing Liu, Hongsuk Park, Alexxai V. Kravitz, Kooresh I. Shoghi, Yu-Hua Tseng, Babak Razani, Akihiro Ikeda, Irfan J. Lodhi   +11 more
doaj   +1 more source

Dietary lipids, gut microbiota and lipid metabolism

Reviews in Endocrine & Metabolic Disorders, 2019
The gut microbiota is a central regulator of host metabolism. The composition and function of the gut microbiota is dynamic and affected by diet properties such as the amount and composition of lipids.
M. Schoeler, R. Caesar
semanticscholar   +1 more source

The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target

International Journal of Molecular Sciences, 2020
The current Coronavirus disease 2019 or COVID-19 pandemic has infected over two million people and resulted in the death of over one hundred thousand people at the time of writing this review.
Mohamed Abu-Farha, T. Thanaraj, M. Qaddoumi, A. Hashem, J. Abubaker, F. Al-Mulla   +5 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Acyl-Lipid Metabolism [PDF]

The Arabidopsis Book, 2010
Acyl lipids in Arabidopsis and all other plants have a myriad of diverse functions. These include providing the core diffusion barrier of the membranes that separates cells and subcellular organelles. This function alone involves more than 10 membrane lipid classes, including the phospholipids, galactolipids, and sphingolipids, and within each class ...
Katherine M. Schmid, Owen Rowland, Jonathan E. Markham, Changcheng Xu, Mats X. Andersson, Ruth Welti, Vincent Arondel, John B. Ohlrogge, Sébastien Baud, Lacey Samuels, Rochus Franke, Hajime Wada, Philippe D. Bates, Amélie A. Kelly, Fred Beisson, Fred Beisson, Ikuo Nishida, Tony R. Larson, Basil S. Shorrosh, Rémi Zallot, Yonghua Li-Beisson, Kenta Katayama, Isabel Molina, David Bird, Debono Allan George, Timithy P. Durrett, Ian A. Graham, Martine Miquel   +27 more
openaire   +7 more sources

Comparison of deuterated leucine, valine, and lysine in the measurement of human apolipoprotein A-I and B-100 kinetics

Journal of Lipid Research, 1990
The production rates of apolipoprotein (apo)B-100 in very low density lipoprotein and in low density lipoprotein and apolipoprotein A-I in high density lipoprotein were determined using a primed-constant infusion of [5,5,5,-2H3]leucine, [4,4,4,-2H3 ...
AH Lichtenstein, JS Cohn, DL Hachey, JS Millar, JM Ordovas, EJ Schaefer   +5 more
doaj   +1 more source

Lipid metabolism in cancer progression and therapeutic strategies

MedComm, 2020
Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy producers, signaling molecules, and source material for the biogenesis
Yan Fu, Tiantian Zou, Xiaotian Shen, P. Nelson, Jiahui Li, Chao Wu, Jimeng Yang, Yan Zheng, C. Bruns, Yue Zhao, L. Qin, Q. Dong   +11 more
semanticscholar   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source