Results 81 to 90 of about 2,639,820 (355)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, Volume 15, Issue 7, Page 1144-1158, July 2025.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Metabolism of high density lipoprotein lipids by the rat liver: evidence for participation of hepatic lipase in the uptake of cholesteryl ester.

Journal of Lipid Research, 1992
In order to determine the role of hepatic lipase in the hepatic uptake and metabolism of high density lipoprotein (HDL) triglycerides, cholesteryl esters, and phospholipids, isolated rat livers were perfused with a reconstituted HDL (rHDL) radiolabeled ...
H Kadowaki, GM Patton, SJ Robins
doaj  

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, Volume 15, Issue 7, Page 1159-1175, July 2025.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Measurement of human apolipoprotein B-48 and B-100 kinetics in triglyceride-rich lipoproteins using [5,5,5-2H3]leucine.

Journal of Lipid Research, 1992
A primed-constant infusion of deuterated leucine was used in humans to determine the maximal level of enrichment at plateau of apolipoprotein (apo)B-48 and apoB-100 which are synthesized in the intestine and liver, respectively, and to compare the ...
AH Lichtenstein, DL Hachey, JS Millar, JL Jenner, L Booth, J Ordovas, EJ Schaefer   +6 more
doaj  

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, Volume 15, Issue 7, Page 1113-1123, July 2025.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

Effect of phosphatidylcholine molecular species on the uptake of HDL triglycerides and cholesteryl esters by the liver.

Journal of Lipid Research, 1993
It has previously been shown that the hydrolysis of high density lipoprotein (HDL) phospholipids by hepatic lipase promotes the hepatic uptake of triglyceride and cholesteryl ester from HDL.
H Kadowaki, GM Patton, SJ Robins
doaj  

Boundaries of photosynthesis: adaptations of carbon fixation in extreme environments

FEBS Open Bio, Volume 15, Issue 7, Page 1028-1040, July 2025.
Photosynthesis faces challenges from environmental extremes of temperature, pH, and salinity, limiting gas diffusion, modifying membrane fluidity, and destabilizing photochemical and biochemical reactions. Photosynthetic organisms have evolved unique adaptations overcoming these stresses and maintaining their photosynthetic activity.
Pere Aguiló‐Nicolau, Concepción Iñiguez, Sebastià Capó‐Bauçà, Jeroni Galmés   +3 more
wiley   +1 more source

Effect of apolipoprotein E phenotype on diet-induced lowering of plasma low density lipoprotein cholesterol.

Journal of Lipid Research, 1994
The National Cholesterol Education Program (NCEP) has recommended that dietary total fat, saturated fat, and cholesterol intake be reduced to < or = 30% of calories, < 10% of calories, and < 300 mg/day, respectively (Step 1 diet) in the general ...
J Lopez-Miranda, J.M. Ordovas, P Mata, A.H Lichtenstein, B Clevidence, J.T Judd, E.J Schaefer   +6 more
doaj  

Deletion of Macrophage Vitamin D Receptor Promotes Insulin Resistance and Monocyte Cholesterol Transport to Accelerate Atherosclerosis in Mice

Cell Reports, 2015
Intense effort has been devoted to understanding predisposition to chronic systemic inflammation because it contributes to cardiometabolic disease. We demonstrate that deletion of the macrophage vitamin D receptor (VDR) in mice (KODMAC) is sufficient to ...
Jisu Oh, Amy E. Riek, Isra Darwech, Katsuhiko Funai, JianSu Shao, Kathleen Chin, Oscar L. Sierra, Geert Carmeliet, Richard E. Ostlund Jr., Carlos Bernal-Mizrachi   +9 more
doaj   +1 more source

Lipid metabolism in T cell signaling and function

Nature Chemical Biology, 2022
S. A. Lim, Wei Su, Nicole M. Chapman, H. Chi   +3 more
semanticscholar   +1 more source