Results 81 to 90 of about 133,206 (305)

Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis [PDF]

, 2017
Current atherosclerosis treatment strategies primarily focus on limiting further cholesteryl esters (CE) accumulation by reducing endogenous synthesis of cholesterol in the liver.
Ghosh, Shobha, He, Hongliang, Korzun, William J., Lancina, Michael G., III, Wang, Jing, Yang, Hu   +5 more
core   +2 more sources

Induction of WNT16 via peptide-mRNA nanoparticle-based delivery maintains cartilage homeostasis [PDF]

, 2020
Osteoarthritis (OA) is a progressive joint disease that causes significant disability and pain and for which there are limited treatment options. We posit that delivery of anabolic factors that protect and maintain cartilage homeostasis will halt or ...
Akk, Antonina, Hu, Ying, Pan, Hua, Pham, Christine T N, Rai, Muhammad Farooq, Wickline, Samuel A, Yan, Huimin   +6 more
core   +2 more sources

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Simple Scattering: Lipid nanoparticle structural data repository

Frontiers in Molecular Biosciences
Lipid nanoparticles (LNPs) are being intensively researched and developed to leverage their ability to safely and effectively deliver therapeutics.
Lee Joon Kim, David Shin, Wellington C. Leite, Hugh O’Neill, Oliver Ruebel, Andrew Tritt, Greg L. Hura, Greg L. Hura   +7 more
doaj   +1 more source

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]

, 2020
Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung, Crumrine, Debra A, Elias, Peter M, Ha, Dae Hyun, Kim, Bogyeong, Kim, Hyun-Keun, Kim, Jin Ock, Kim, Sungeun, Kwon, Hyuck Hoon, Lee, Joon, Lee, Jun Ho, Lee, Yerin, Lim, Jihye, Meyer, Jason M, Park, Gyeong-Hun, Park, Kyungho, Park, Sejeong, Shin, Kyong-Oh, Wakefield, Joan S, Yi, Yong Weon   +19 more
core   +1 more source

Resveratrol in Solid Lipid Nanoparticles

Journal of Dispersion Science and Technology, 2012
This article investigates the possibility of producing solid lipid nanoparticles (SLN) as protective vehicle of resveratrol, an antioxidant characterized by a fast trans-cis isomerization. SLN aqueous dispersions were produced by hot melt homogenization technique and characterized.
CARLOTTI, Maria Eugenia, SAPINO, Simona, UGAZIO, Elena, GALLARATE, Marina, Morel S.   +4 more
openaire   +2 more sources

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

Transferrin-Decorated Protein-Lipid Hybrid Nanoparticle Efficiently Delivers Cisplatin and Docetaxel for Targeted Lung Cancer Treatment

Drug Design, Development and Therapy, 2021
Kaiping Mao,1 Weina Zhang,2 Lan Yu,3 Yi Yu,1 Haixia Liu,1 Xiaotao Zhang3 1Department of Thoracic surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People’s Republic of China; 2Department of Plastic surgery, The Affiliated Hospital ...
Mao K, Zhang W, Yu L, Yu Y, Liu H, Zhang X   +5 more
doaj  

Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles

Bioengineering & Translational Medicine, 2023
Although mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for pulmonary delivery has not yet fully been established. A major barrier to this therapeutic goal is their instability during aerosolization for local delivery ...
Mae M. Lewis, Melissa R. Soto, Esther Y. Maier, Steven D. Wulfe, Sandy Bakheet, Hannah Obregon, Debadyuti Ghosh   +6 more
doaj   +1 more source

Microplastics from Wearable Bioelectronic Devices: Sources, Risks, and Sustainable Solutions

Advanced Functional Materials, EarlyView.
Bioelectronic devices (e.g., e‐skins) heavily rely on polymers that at the end of their life cycle will generate microplastics. For research, a holistic approach to viewing the full impact of such devices cannot be overlooked. The potential for devices as sources for microplastics is raised, with mitigation strategies surrounding polysaccharide and ...
Conor S. Boland
wiley   +1 more source