Results 151 to 160 of about 1,423,524 (284)

Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake

, 2014
Hyun-Jong Cho1, Jin Woo Park2, In-Soo Yoon2, Dae-Duk Kim31College of Pharmacy, Kangwon National University, Chuncheon, 2College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam, 3College of Pharmacy and Research ...
Park JW, Kim DD, Yoon IS, Cho HJ
core  

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Lipid Nanoparticles at the Crossroads of Chemistry and Medicine: A Tutorial. [PDF]

ACS Nanosci Au
Rogado MT, Wang A, Zeng S, Wang Z, Burda C.   +4 more
europepmc   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Comprehensive Evaluation of Gastrointestinal Factors Influencing the Stability and Function of mRNA-Encapsulated Lipid Nanoparticles. [PDF]

Drug Dev Res
Shinkai T, Ogawa K, Mohamed MS, Ozeki T.
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Lipoprotein Corona Reshapes the Internal Structure of Lipid Nanoparticles. [PDF]

ACS Nano
Caselli L, Rojas-Rodríguez M, Pacciani V, Calamai M, Frigerio R, Zendrini A, Sanità G, Esposito E, Leung A, Wacklin-Knecht H, Humphreys B, Arosio P, Cardellini J, Berti D.   +13 more
europepmc   +1 more source

Solid lipid nanoparticles: a new cationic lipid matrix composition for gene transfer,

, 2006
Solid lipid nanoparticles: a new cationic lipid matrix composition for gene ...
FORNI, Flavio, RUOZI, Barbara, VIGHI, Eleonora, BATTINI, Renata, LEO, Eliana Grazia, MONTANARI, Monica   +5 more
core  

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

JAG1-siRNA-Lipid Nanoparticles Suppress Infantile Hemangioma Angiogenesis. [PDF]

Pharmaceutics
Teng Y, Xu X, Gao J, Liu J.
europepmc   +1 more source