Results 171 to 180 of about 1,423,524 (284)

Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles. [PDF]

Nat Nanotechnol
Liang D, Qi Y, Han H, Ahmadian N, Gao K, Sapasap K, Zhang Y, Guo S, Lawanprasert A, Pimcharoen S, Zhao S, Del Buono MT, Xia H, Enders ZO, Burgstone BW, Calio A, Dankar N, Lu B, Qi LS, Wang A, Murthy N.   +20 more
europepmc   +1 more source

Ionizable Cholesterol-Integrated Lipid Nanoparticles for Efficient siRNA Delivery to Solid Tumors. [PDF]

ChemMedChem
Kang S, Nguyen DT, Jon S.
europepmc   +1 more source

The Effect of Ligand Reactivity and Carrier Mechanics on Thiol‐Mediated Cellular Uptake for miRNA Nano‐Drugs

Advanced Science, EarlyView.
The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang, Hui Wang, Hao Zhang, Zhenkuan Cao, Zehui Liu, Siying Li, Hongda Wang, Yuping Shan   +7 more
wiley   +1 more source

Recent Advances in Lipid Nanoparticles for Cancer Vaccines: From Antigen Delivery to Personalized Immunotherapy. [PDF]

Int J Mol Sci
Rachamala HK, Angom RS, Marepally S.
europepmc   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Ionizable Lipid-Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties. [PDF]

Adv Mater
Thatte AS, Nachod BE, Baena J, Muscat-Rivera J, Chaboub L, Safford HC, Geisler HC, Yamagata HM, Ang MJY, Kegel M, Poirier A, Tong ER, Zhong Z, Shi Q, Wang J, Battistini E, Zeng Y, Hamilton AG, Swingle KL, Weissman D, Melamed JR, Mitchell MJ.   +21 more
europepmc   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

Colloidal Light Scattering Distorts Fluorometric Quantification of mRNA in Lipid Nanoparticles. [PDF]

Curr Issues Mol Biol
Klusek A, Adasiewicz K, Bystrzejewska A, Rudzki PJ, Wieczorek M, Juszczyk E.   +5 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

The transformative potential of lipid nanoparticles tailored for acute myeloid leukemia immunotherapy. [PDF]

Front Immunol
Kamb A, Welch JS.
europepmc   +1 more source