Results 21 to 30 of about 117,691 (310)

Lipid–Polymer Hybrid Nanosystems: A Rational Fusion for Advanced Therapeutic Delivery

Journal of Functional Biomaterials, 2023
Lipid nanoparticles (LNPs) are spherical vesicles composed of ionizable lipids that are neutral at physiological pH. Despite their benefits, unmodified LNP drug delivery systems have substantial drawbacks, including a lack of targeted selectivity, a ...
Shweta Jain, Mudit Kumar, Pushpendra Kumar, Jyoti Verma, Jessica M. Rosenholm, Kuldeep K. Bansal, Ankur Vaidya   +6 more
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Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

Experimental and Molecular Medicine, 2023
Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn ...
Yeji Lee, Michaela Jeong, Jeongeun Park, Hyein Jung, Hyukjin Lee   +4 more
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Lipid nanoparticles with ionizable lipids: Statistical aspects

Physical Review E, 2022
Lipid nanoparticles (LNPs) with size ∼100 nm are now used for fabrication of a new generation of drugs and antiviral vaccines. To optimize their function or, more specifically, interaction with cell membranes, their composition often includes ionizable lipids which are neutral or cationic (after association with H^{+}).
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Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines

Vaccines, 2021
COVID-19 vaccines have been developed with unprecedented speed which would not have been possible without decades of fundamental research on delivery nanotechnology.
Thai Thanh Hoang Thi, Estelle J. A. Suys, Jung Seok Lee, Dai Hai Nguyen, Ki Dong Park, Nghia P. Truong   +5 more
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Sustained Cytotoxicity of Wogonin on Breast Cancer Cells by Encapsulation in Solid Lipid Nanoparticles

Nanomaterials, 2018
While wogonin has been known to have cytotoxicity against various cancer cells, its bioavailability and cytotoxicity are low due to its low water solubility.
Jong-Suep Baek, Young-Guk Na, Cheong-Weon Cho   +2 more
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Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir

Molecules, 2021
Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute ...
Haniza Hassan, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir   +5 more
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Ultrasmall Solid-Lipid Nanoparticles via the Polysorbate Sorbitan Phase-Inversion Temperature Technique: A Promising Vehicle for Antioxidant Delivery into the Skin

Pharmaceutics, 2023
Solid lipid nanoparticles promote skin hydration via stratum corneum occlusion, which prevents water loss by evaporation, and via the reinforcement of the skin’s lipid-film barrier, which occurs through the adhesion of the nanoparticles to the stratum ...
Francesca Della Sala, Assunta Borzacchiello, Chiara Dianzani, Elisabetta Muntoni, Monica Argenziano, Maria Teresa Capucchio, Maria Carmen Valsania, Annalisa Bozza, Sara Garelli, Maria Di Muro, Franco Scorziello, Luigi Battaglia   +11 more
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Lipid-Polyglutamate Nanoparticle Vaccine Platform

ACS Applied Materials & Interfaces, 2021
Peptide-based subunit vaccines are attractive in view of personalized cancer vaccination with neo-antigens, as well as for the design of the newest generation of vaccines against infectious diseases. Key to mounting robust antigen-specific immunity is delivery of antigen to antigen-presenting (innate immune) cells in lymphoid tissue with concomitant ...
Dorien Van Lysebetten, Alessio Malfanti, Kim Deswarte, Kaloian Koynov, Bianka Golba, Tingting Ye, Zifu Zhong, Sabah Kasmi, Alexander Lamoot, Yong Chen, Simon Van Herck, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Sunil A. David, María J. Vicent, Stefaan De Koker, Bruno G. De Geest   +17 more
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Biophysical analysis of lipidic nanoparticles [PDF]

Methods, 2020
Biological nanoparticles include liposomes, extracellular vesicle and lipid-based discoidal systems. When studying such particles, there are several key parameters of interest, including particle size and concentration. Measuring these characteristics can be of particular importance in the research laboratory or when producing such particles as ...
Rozo, Annaïg J., Cox, Megan H., Devitt, Andrew, Rothnie, Alice J., Goddard, Alan D.   +4 more
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Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system

Bioactive Materials, 2017
Poly lactic acid is a biodegradable, biocompatible, and non-toxic polymer, widely used in many pharmaceutical preparations such as controlled release formulations, parenteral preparations, surgical treatment applications, and tissue engineering.
Vivek Dave, Renu Bala Yadav, Kriti Kushwaha, Sachdev Yadav, Swapnil Sharma, Udita Agrawal   +5 more
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