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Preclinical Evaluation of Lipid-Based Nanosystems
Pharmaceutics, 2021 The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles—SLN, and nanostructured lipid carriers—NLC), nanoemulsions, and liposomes, among others, is widespread [...]
Ana Catarina Silva +1 more
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From lipids to lipid nanoparticles to mRNA vaccines [PDF]
Nature Reviews Materials, 2021 Lipid nanoparticles are essential to mRNA vaccines. The groundwork for lipid-based drug delivery systems was laid more than 40 years ago in the lab of Pieter Cullis, Professor at the University of British Columbia. Nature Reviews Materials talks to Pieter Cullis about the history and future of lipid nanoparticle-nucleic acid drugs.
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Editorial—Current Insights on Lipid-Based Nanosystems
Pharmaceuticals, 2022 Lipid-based nanosystems, including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), cationic lipid nanoparticles, nanoemulsions and liposomes, have been extensively studied to improve drug delivery through different administration
Ana Catarina Silva +2 more
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Review article on nanoemulsions and nanostructured lipid carriers [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2018 Lipid nanoparticles, including nanoemulsions (NEs) and nanostructured lipid carriers (NLCs) are colloidal carriers with a lipid matrix that is solid at body temperature.
mamdouh ghorab +3 more
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Use of Microfluidics to Prepare Lipid-Based Nanocarriers
Pharmaceutics, 2023 Lipid-based nanoparticles (LBNPs) are an important tool for the delivery of a diverse set of drug cargoes, including small molecules, oligonucleotides, and proteins and peptides. Despite their development over the past several decades, this technology is
Alicia Vogelaar +4 more
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Challenges in the Physical Characterization of Lipid Nanoparticles [PDF]
Pharmaceutics, 2021 Nano-sized drug transporters have become an efficient approach with considerable commercial values. Nanomedicine is not only limited to drug delivery by means of different administration routes, such as intravenous, oral, transdermal, nasal, pulmonary, and more, but also has applications in a multitude of areas, such as a vaccine, antibacterial ...
Supandeep Singh Hallan +3 more
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Journal of Nanobiotechnology, 2022 Liver cancer is considered one of the deadliest diseases with one of the highest disease burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is considered to be the most common type. Multiple conventional approaches are
Khaled Mahmoud +3 more
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, 2021 Emerging therapeutic treatments based on the production of proteins by delivering mRNA have become increasingly important in recent times. While lipid nanoparticles (LNPs) are approved vehicles for small interfering RNA delivery, there are still ...
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Lipid–Polymer Hybrid Nanosystems: A Rational Fusion for Advanced Therapeutic Delivery
Journal of Functional Biomaterials, 2023 Lipid nanoparticles (LNPs) are spherical vesicles composed of ionizable lipids that are neutral at physiological pH. Despite their benefits, unmodified LNP drug delivery systems have substantial drawbacks, including a lack of targeted selectivity, a ...
Shweta Jain +6 more
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Delivery of oligonucleotides with lipid nanoparticles [PDF]
Advanced Drug Delivery Reviews, 2015 Since their inception in the 1980s, oligonucleotide-based (ON-based) therapeutics have been recognized as powerful tools that can treat a broad spectrum of diseases. The discoveries of novel regulatory methods of gene expression with diverse mechanisms of action are still driving the development of novel ON-based therapeutics.
Yuhua, Wang +3 more
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