Results 21 to 30 of about 210,435 (207)

Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

Experimental and Molecular Medicine, 2023
Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn ...
Yeji Lee, Michaela Jeong, Jeongeun Park, Hyein Jung, Hyukjin Lee   +4 more
doaj   +1 more source

Mechanism of cellular uptake of genotoxic silica nanoparticles. [PDF]

, 2012
Mechanisms for cellular uptake of nanoparticles have important implications for nanoparticulate drug delivery and toxicity. We have explored the mechanism of uptake of amorphous silica nanoparticles of 14 nm diameter, which agglomerate in culture medium ...
Brown, AP, Hondow, NS, Jeuken, LJ, Krzemiński, L, Mu, Q, Routledge, MN   +5 more
core   +3 more sources

A saposin-lipoprotein nanoparticle system for membrane proteins. [PDF]

, 2016
A limiting factor in membrane protein research is the ability to solubilize and stabilize such proteins. Detergents are used most often for solubilizing membrane proteins, but they are associated with protein instability and poor compatibility with ...
Armache, Jean-Paul, Briggs, John AG, Cheng, Yifan, Flayhan, Ali, Frauenfeld, Jens, Garoff, Henrik, Guettou, Fatma, Jegerschöld, Caroline, Löving, Robin, Löw, Christian, Moberg, Per, Nordlund, Pär, Sonnen, Andreas F-P, Zhu, Lin   +13 more
core   +2 more sources

Lipid nanoparticles with ionizable lipids: Statistical aspects

Physical Review E, 2022
Lipid nanoparticles (LNPs) with size ∼100 nm are now used for fabrication of a new generation of drugs and antiviral vaccines. To optimize their function or, more specifically, interaction with cell membranes, their composition often includes ionizable lipids which are neutral or cationic (after association with H^{+}).
openaire   +2 more sources

Hybrid plasmonic photoreactors as visible light-mediated bactericides [PDF]

, 2020
Photocatalytic compounds and complexes, such as tris(bipyridine)ruthenium(II), [Ru(bpy)3]2+, have recently attracted attention as light-mediated bactericides that can help to address the need for new antibacterial strategies.
An, Xingda, Liu, Pinghua, Naowarojna, Nathchar, Reinhard, Björn M.   +3 more
core   +1 more source

Sustained Cytotoxicity of Wogonin on Breast Cancer Cells by Encapsulation in Solid Lipid Nanoparticles

Nanomaterials, 2018
While wogonin has been known to have cytotoxicity against various cancer cells, its bioavailability and cytotoxicity are low due to its low water solubility.
Jong-Suep Baek, Young-Guk Na, Cheong-Weon Cho   +2 more
doaj   +1 more source

Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines

Vaccines, 2021
COVID-19 vaccines have been developed with unprecedented speed which would not have been possible without decades of fundamental research on delivery nanotechnology.
Thai Thanh Hoang Thi, Estelle J. A. Suys, Jung Seok Lee, Dai Hai Nguyen, Ki Dong Park, Nghia P. Truong   +5 more
doaj   +1 more source

Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir

Molecules, 2021
Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute ...
Haniza Hassan, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir   +5 more
doaj   +1 more source

Can pulsed electromagnetic fields trigger on-demand drug release from high-tm magnetoliposomes? [PDF]

, 2018
Recently, magnetic nanoparticles (MNPs) have been used to trigger drug release from magnetoliposomes through a magneto-nanomechanical approach, where the mechanical actuation of the MNPs is used to enhance the membrane permeability.
Apollonio, Francesca, Casadei, Maria Antonietta, Della Valle, Elena, Liberti, Micaela, Nardoni, Martina, Paolicelli, Patrizia, Petralito, Stefania, Relucenti, Michela   +7 more
core   +2 more sources

Ultrasmall Solid-Lipid Nanoparticles via the Polysorbate Sorbitan Phase-Inversion Temperature Technique: A Promising Vehicle for Antioxidant Delivery into the Skin

Pharmaceutics, 2023
Solid lipid nanoparticles promote skin hydration via stratum corneum occlusion, which prevents water loss by evaporation, and via the reinforcement of the skin’s lipid-film barrier, which occurs through the adhesion of the nanoparticles to the stratum ...
Francesca Della Sala, Assunta Borzacchiello, Chiara Dianzani, Elisabetta Muntoni, Monica Argenziano, Maria Teresa Capucchio, Maria Carmen Valsania, Annalisa Bozza, Sara Garelli, Maria Di Muro, Franco Scorziello, Luigi Battaglia   +11 more
doaj   +1 more source