Results 151 to 160 of about 273,083 (353)

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

Advanced Science, EarlyView.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang, Bin Li, Zhijin Fan, Yan Yan, Fei Ma, Changting He, Shiping Liu, Mingliang Pan, Zhou Pan, Huijuan Wang, Xinting Fu, Jiamei Wang, Yue Jia, Qin Gu, Duo Jiang, Xueting Liu, Bohua Ren, Qinqin Wang, Yuehua Hei, Han Duan, Yanqiu Wu, Zihui Wei, Liying Zhan, Yuhui Liao   +23 more
wiley   +1 more source

Correlation of Lipid Peroxidation with Glycated Haemoglobin Levels in Diabetes Mellitus

Online Journal of Health & Allied Sciences, 2011
Reactive oxygen species are crucial to normal biological processes; they are potentially dangerous and are commonly referred to as prooxidants. The reactive oxygen intermediates can cause direct cellular injury by including lipid and protein peroxidation
Varashree BS, Gopalakrishna Bhat P
doaj  

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

and Covalent Binding in the Rat Rationale for the Use of Hyperbaric Oxygen to Treat Carbon Tetrachloride Ingestion

, 2014
. CC14 exerts its toxicity through its metabolites, including the free radicals CCl; and CC13W. Oxygen strongly inhibits the hepatic cytochrome P-450mediated formation of CC1I from CC14 and promotes the conversion of CCI; to CC1300.
Microsomal Lipid Peroxidation, Raymond F. Burk, Kuldeep Patel, Tetrachloride-induced Hepatic, James M. Lane   +4 more
core  

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

The effects of therapeutic concentrations ofamisulpride andrisperidone on human plasma lipid peroxidation – invitro studies

, 2011
Introduction: Antipsychotics may in different ways affect the oxidative stress measured by plasma lipid peroxidation. Probably some of them may intensify the oxidative balance disturbances occurring in schizophrenia.
Rabe-Jabłońska, Jolanta, Jolanta Rabe-Jabłońska, Anna Dietrich-Muszalska, Justyna Kopka, Anna Kwiatkowska, Dietrich-Muszalska, Anna, Kopka, Justyna, Kwiatkowska, Anna   +7 more
core  

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Non-Linearity Effect of Low-Doses γ-Radiation on Essential Metals, Lipid Peroxidation and Metallothionein Levels in Rats [PDF]

, 2011
A. Hawas, Aisha A. Saad-El-Din, R Agget, N Davis, P Avti, C Pathak, S Kumar, G Kaushik, T Kaushik, A Farooque, K Khanduja, S Sharma, M Bienengrber, S Forderkunz, D Klein, K Summer, L Cai, M Satoh, C Tohyama, M Cherian, E Calabrese, L Baldwin, E Calabrese, L Baldwin, E Calabrese, K Bachmann, A Bailer, P Bolger, J Borak, L Cai, N Cedergreen, M Cherian, C Chiueh, T Clarkson, R Cook, D Diamond, D Doolittle, M Dorato, S Duke, L Feinendegen, D Gardner, R Hart, K Hastings, A Hayes, G Hoffmann, J Ives, Z Jaworowski, T Johnson, W Jonas, N Kaminski, J Keller, J Klaunig, T Knudsen, W Kozumbo, T Lettieri, S Liu, A Maisseu, K Maynard, E Masoro, R Mcclellan, H Mehendale, C Mothersill, D Newlin, H Nigg, F Oehme, R Phalen, M Philbert, S Rattan, J Riviere, J Rodrick, R Sapolsky, B Scott, C Seymour, D Sinclair, J Smith-Sonneborn, E Snow, L Spear, D Stevenson, Y Thomas, M Tubiana, G Williams, M Mattson, J Davis, D Svendsgaard, L Edward, L Feinendegen, L Feinendegen, L Feinendegen, M Pollycove, R Neumann, M Golden, G Hoffmann, G Hoffmann, W Stempsey, B Kirkwood, W Mertz, R Mitchel, S Okada, C Pathak, P Avti   +99 more
openalex   +1 more source