Results 141 to 150 of about 869,159 (249)

and Covalent Binding in the Rat Rationale for the Use of Hyperbaric Oxygen to Treat Carbon Tetrachloride Ingestion

, 2014
. CC14 exerts its toxicity through its metabolites, including the free radicals CCl; and CC13W. Oxygen strongly inhibits the hepatic cytochrome P-450mediated formation of CC1I from CC14 and promotes the conversion of CCI; to CC1300.
Microsomal Lipid Peroxidation, Raymond F. Burk, Kuldeep Patel, Tetrachloride-induced Hepatic, James M. Lane   +4 more
core  

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Lipid peroxidation impacts orthoflavivirus infection in a virus-dependent manner. [PDF]

Cell Death Dis
Vu KCT, Grande YF, Bierau L, Schauflinger M, Spremberg E, Ku JWK, Hehner J, Schöbel A, Herker E.   +8 more
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

NCOA4 as a regulatory switch linking DNA damage to lipid peroxidation in radiation response. [PDF]

Front Cell Dev Biol
Yi P, Qiu L, Han H, Wang T, Bai Y.
europepmc   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Spatial Association Between Polyamine Metabolism and Lipid Peroxidation in Different Pathological Regions of Glioblastoma. [PDF]

Biomedicines
Qu Z, Guo K, Xiang X, An Y, Lei T, Liu A, Wang Y, Chen D, Chen H, Zhang Z, Qin J, He J, Li X, Liu F, Li Y.   +14 more
europepmc   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

HDL, lipid peroxidation, and atherosclerosis1

Journal of Lipid Research, 2009
Baohai Shao, Jay W. Heinecke
doaj   +1 more source

Systemic Lipid Peroxidation and Colorectal Cancer Risk: A Time-Varying Relationship. [PDF]

Int J Cancer
Yang G, Milne GL, Nogueira MS, Gao YT, Lan Q, Yi H, Shu XO, Zheng W, Chen Q.   +8 more
europepmc   +1 more source