Results 181 to 190 of about 1,632,742 (358)

Cell Viability, Drug Screening, and Mechanism Study Under Mild Phototherapy Integrated Chemotherapy (PIC)

open access: yesAdvanced Science, EarlyView.
Mild phototherapy integrated chemotherapy (mild‐PIC) monitored by real‐time impedance spectroscopy enhances drug efficacy in liver cancer via the “More Light‐Aiding, Less Bonding (LALB)” mechanism, achieving higher targeting with lower toxicity. Abstract Phototherapy integrated chemotherapy (PIC) offers a promising cancer treatment strategy as single ...
Tongge Li   +15 more
wiley   +1 more source

Chloroplast Fibrillin‐Mediated α‐Tocopherol Biosynthesis Impaired by a Virus to Enhance Infection and to Improve Drought Tolerance

open access: yesAdvanced Science, EarlyView.
ToCV‐encoded p22 targets chloroplast plastoglobules (PGs) via directly binding PG structural protein FBN1.1, reducing the size of PG and inhibiting α‐tocopherol biosynthesis via competing with tocopherol cyclase (VTE1). Consequently, the elevated chloroplast ROS not only creates a suitable cellular environment for efficient ToCV infection but also ...
Sijia Liu   +8 more
wiley   +1 more source

Inhibition of lipid peroxidation with the lazaroid U74500A attenuates ischemia-reperfusion injury in a canine orthotopic heart transplantation model [PDF]

open access: bronze, 1996
Yoshihisa Tanoue   +7 more
openalex   +1 more source

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

open access: yesAdvanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan   +11 more
wiley   +1 more source

Tackling Allergic Airway Inflammation with Organic Sheet‐Like Nanoplatforms by Targeted Elimination of Epithelial Small Extracellular Vesicles

open access: yesAdvanced Science, EarlyView.
In this work, “inorganic‐free” nanosheets, named PNSE are developed using template‐based synthesis technology. The functionalized organic nanosheets exhibit low cytotoxicity, mild protein adsorption, and potent binding efficacy to epithelial sEVs.
Zhaoxu Tu   +11 more
wiley   +1 more source

Ferroptosis: Death by Lipid Peroxidation.

open access: yesTrends in Cell Biology, 2016
W. Yang, B. Stockwell
semanticscholar   +1 more source

Trained Immunity Exacerbates Inflammatory Arthritis Progression via Promoting Synovial Fibroblast Ferroptotic Resistance

open access: yesAdvanced Science, EarlyView.
β‐glucan‐induced trained immunity reprograms macrophages toward hyperinflammation, exacerbating inflammatory arthritis. In a collagen‐induced arthritis model, trained macrophages intensify disease severity and confer ferroptosis resistance in synovial cells via IL‐1β/NAT10‐mediated FSP1 mRNA modification.
Haibo Su   +12 more
wiley   +1 more source

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress‐Related Male Reproductive Dysfunction

open access: yesAdvanced Science, EarlyView.
Psychological stress activates the sympathetic–adrenal axis, elevating norepinephrine (NE) and suppressing reproductive hormones, thereby impairing male reproduction. Excess NE overactivates and desensitizes β‐adrenergic receptors (β‐ARs), triggering Sertoli cell ferroptosis and disrupting spermatogenesis.
Lingyu Zhang   +12 more
wiley   +1 more source

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