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Paraquat and Lipid Peroxidation [PDF]
Archives of Internal Medicine, 1982 To the Editor. —In the AugustArchives(1981;141:1169-1171), Yasaka et al reported an increase in lipid peroxidation (as measured by serum malondialdehyde levels) after ingestion of paraquat, a bipyridinium compound widely used as a herbicide. The authors suggested that the serum malondialdehyde may have originated from passage of the blood through the ...
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Lipid peroxidation in neurodegeneration
Clinica Chimica Acta, 2019Neurodegenerative diseases have great social and economic impact and cause millions of deaths every year. The potential molecular mechanisms in these pathologies have been widely studied and implicate lipid peroxidation as an important factor in the development of neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases ...
Carmen Peña-Bautista +3 more
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Lipid peroxidation in erythrocytes
Chemistry and Physics of Lipids, 1987Erythrocytes might be expected to be highly susceptible to peroxidation. Their membranes are rich in polyunsaturated fatty acids; they are continuously exposed to high concentrations of oxygen; and they contain a powerful transition metal catalyst. In fact, autoxidation is held in check in vivo by extremely efficient protective antioxidant mechanisms ...
Hans Dierck Waller, Michael R. Clemens
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Measurement of Lipid Peroxidation
Free Radical Research, 1998Lipid peroxidation results in the formation of conjugated dienes, lipid hydroperoxides and degradation products such as alkanes, aldehydes and isoprostanes. The approach to the quantitative assessment of lipid peroxidation depends on whether the samples involve complex biological material obtained in vivo, or whether the samples involve relatively ...
L J Roberts nd, Kevin P. Moore
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Lipid peroxidation in homocysteinaemia
Journal of Inherited Metabolic Disease, 1992Homocysteinaemia due to cystathione synthase deficiency (CSD: McKusick 236200) is a rare autosomal recessive inborn error of methionine metabolism. The most life-threatening complications caused by CSD are thromboembolism and vascular abnormalities.
R.A. de Abreu +7 more
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Peroxidation of liposomal lipids
European Biophysics Journal, 2007Free radicals, formed via different mechanisms, induce peroxidation of membrane lipids. This process is of great importance because it modifies the physical properties of the membranes, including its permeability to different solutes and the packing of lipids and proteins in the membranes, which in turn, influences the membranes' function. Accordingly,
Ilya Pinchuk +2 more
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Critical Reviews in Oncology/Hematology, 1993
Lipid peroxidation, firstly described as a mechanism of lipid deterioration by chemists, is now considered as a major mechanism of elementary lesion in living cells, and in many cases the major cause for their death. In living animals, it was firstly described to increase after irradiation [23,32,252] and then in vitamin E deficiency [57,258,259].
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Lipid peroxidation, firstly described as a mechanism of lipid deterioration by chemists, is now considered as a major mechanism of elementary lesion in living cells, and in many cases the major cause for their death. In living animals, it was firstly described to increase after irradiation [23,32,252] and then in vitamin E deficiency [57,258,259].
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1997
Publisher Summary This chapter presents the fundamental characteristics of oxygen radical-induced lipid peroxidation (LP) as they relate to the pathophysiology of focal and global cerebral ischemia and subarachnoid hemorrhage (SAH). There is extensive biochemical, physiological, and pharmacological evidence in support of an important role of LP in ...
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Publisher Summary This chapter presents the fundamental characteristics of oxygen radical-induced lipid peroxidation (LP) as they relate to the pathophysiology of focal and global cerebral ischemia and subarachnoid hemorrhage (SAH). There is extensive biochemical, physiological, and pharmacological evidence in support of an important role of LP in ...
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Lipid peroxidation in spermatozoa
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1973Ram spermatozoa produce aerobically an organic peroxide which can be determined quantitatively by the thiobarbituric acid reaction. The reaction is more intense in spermatozoa that have been stored at 5°C. Cold shock and homogenization release from spermatozoa a substance, presumably a lipid, which provides the substrate for peroxidation.
Thaddeus Mann, Richard A. L. Jones
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Mechanisms of lipid peroxidation
Journal of Free Radicals in Biology & Medicine, 1985This article provides an overview of how peroxidation of unsaturated lipids takes place and how it can be measured. Several different aspects of free-radical-mediated lipid peroxidation are discussed, including: the catalytic role of chelated iron and other redox metal ions; induction by reducing agents such as superoxide, ascorbate, and xenobiotic ...
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