Results 91 to 100 of about 1,129,041 (391)

Role of lipid rafts and GM1 in the segregation and processing of prion protein.

PLoS ONE, 2014
The prion protein (PrPC) is highly expressed within the nervous system. Similar to other GPI-anchored proteins, PrPC is found in lipid rafts, membrane domains enriched in cholesterol and sphingolipids.
Laura Botto, Diana Cunati, Silvia Coco, Silvia Sesana, Alessandra Bulbarelli, Emiliano Biasini, Laura Colombo, Alessandro Negro, Roberto Chiesa, Massimo Masserini, Paola Palestini   +10 more
doaj   +1 more source

The Different Hues of Lipid Rafts [PDF]

Science, 2002
Segregation of lipids and proteins of the plasma membrane into microdomains called lipid rafts is known to be important for many biological processes including signal transduction and pathogen invasion. In his Perspective, van Meer explains new findings ( Zacharias et al.) that reveal how lipid moieties attached to proteins instruct
openaire   +4 more sources

Lipid rafts, cholesterol, and the brain [PDF]

Neuropharmacology, 2008
Lipid rafts are specialized membrane microdomains that serve as organizing centers for assembly of signaling molecules, influence membrane fluidity and trafficking of membrane proteins, and regulate different cellular processes such as neurotransmission and receptor trafficking.
Zeljka Korade, Anne K. Kenworthy
openaire   +3 more sources

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

A sensitive S-Trap-based approach to the analysis of T cell lipid raft proteome

Journal of Lipid Research, 2020
The analysis of T cell lipid raft proteome is challenging due to the highly dynamic nature of rafts and the hydrophobic character of raft-resident proteins.
Cerina Chhuon, Shao-Yu Zhang, Vincent Jung, Daniel Lewandowski, Joanna Lipecka, André Pawlak, Dil Sahali, Mario Ollero, Ida Chiara Guerrera   +8 more
doaj   +1 more source

Receptor/Raft Ratio Is a Determinant for LRP6 Phosphorylation and WNT/β-Catenin Signaling

Frontiers in Cell and Developmental Biology, 2021
Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the membrane and play a vital role in the formation and activation of receptor/protein complexes.
Fiete Haack, Till Köster, Adelinde M. Uhrmacher   +2 more
doaj   +1 more source

Lipid Rafts and the Regulation of Exocytosis [PDF]

Traffic, 2004
Exocytosis is the process whereby intracellular fluid‐filled vesicles fuse with the plasma membrane, incorporating vesicle proteins and lipids into the plasma membrane and releasing vesicle contents into the extracellular milieu. Exocytosis can occur constitutively or can be tightly regulated, for example, neurotransmitter release from nerve endings ...
Declan J. James, Luke H. Chamberlain, Christine Salaün   +2 more
openaire   +3 more sources

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Lipid raft-dependent endocytosis: a new route for hepcidin-mediated regulation of ferroportin in macrophages

Haematologica, 2010
Background Expression of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and is decreased by hepcidin. We previously showed that ferroportin is present in specific cell surface domains suggestive of lipid ...
Anne Auriac, Alexandra Willemetz, François Canonne-Hergaux   +2 more
doaj   +1 more source