Results 141 to 150 of about 1,129,041 (391)

A Simulation Study on Multicomponent Lipid Bilayer

, 2005
Simulation of a multicomponent lipid bilayer having a fixed percentage of cholesterol is done to study phase transition leading to domain formation.
Anderson, Anderson, Banerjee, Banerjee, Ben-Shaul, Bloom, Brown, Brown, Brown, de Miguel, Doniach, Ermoshkin, Evans, Ferrenberg, Harrison, Jacobson, Jayashree Saha, Lee, May, Mouritsen, Nielsen, Nielsen, Radhakrishnan, Sabra, Scherfeld, Simons, Simons, Srilekha Banerjee, Zhang   +28 more
core   +1 more source

Physiological pH Transition‐Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles

Advanced Science, EarlyView.
Physiological pH transitions modulate protein corona dynamics on nanoparticles, altering their cellular uptake and inflammatory responses. Acidic pHs enhance protein adsorption, induce structural changes, and promote cellular uptake. Simultaneously, inflammatory responses are reduced due to altered protein composition, including decreased ...
Yuting Ge, Fangqin Fu, Yu Gao, Tianchang He, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang   +7 more
wiley   +1 more source

Atomistic simulations of a multicomponent asymmetric lipid bilayer

, 2012
The cell membrane is inherently asymmetric and heterogeneous in its composition, a feature that is crucial for its function. Using atomistic molecular dynamics simulations, the physical properties of a 3-component asymmetric mixed lipid bilayer system ...
Polley, Anirban, Rao, Madan, Vemparala, Satyavani   +2 more
core   +1 more source

Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking [PDF]

, 2009
We have previously reported that galectin-4, a tandem repeat-type galectin, regulates the raft-dependent delivery of glycoproteins to the apical brush border membrane of enterocyte-like HT-29 cells.
Altschuler Y., Gabius H.J., Gendler S., Gouyer V., Hennebicq-Reig S., Huang J., Ligtenberg M.J., Ninomiya H., Yamashita K.   +8 more
core   +2 more sources

Drug Delivery Technologies for the Treatment of Age‐Related Macular Degeneration

Advanced Science, EarlyView.
There are multiple therapeutic agents available for the treatment of both dry age‐related macular degeneration (AMD) and wet AMD. It is essential to continue innovation by introducing new drug delivery technologies that can incorporate those along with patient compliance and the accessibility of the technology into the early stages of research and ...
J Jesus Rodriguez‐Cruz, Jessica Cutrufello, Michael Lam, Shreya Nallaparaju, Nicholas A. Peppas   +4 more
wiley   +1 more source

Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts.

PLoS ONE, 2015
Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways.
Chun-Lin Chen, Ying-Pin Chen, Ming-Wei Lin, Yaw-Bin Huang, Fang-Rong Chang, Tsai-Hui Duh, Deng-Chyang Wu, Wei-Chiang Wu, Yu-Chen Kao, Pei-Hua Yang   +9 more
doaj   +1 more source

Computation of a Theoretical Membrane Phase Diagram, and the Role of Phase in Lipid Raft-Mediated Protein Organization

, 2018
Lipid phase heterogeneity in the plasma membrane is thought to be crucial for many aspects of cell signaling, but the physical basis of participating membrane domains such as "lipid rafts" remains controversial.
Baird, Barbara, Holowka, David, Mitra, Eshan D., Sethna, James P., Whitehead, Samuel C.   +4 more
core   +1 more source

Lipid Raft Endocytosis and Exosomal Transport Facilitate Extracellular Trafficking of Annexin A2*

Journal of Biological Chemistry, 2011
Annexin A2 (AnxA2), a Ca2+-dependent phospholipid-binding protein, is known to associate with the plasma membrane and the endosomal system. Within the plasma membrane, AnxA2 associates in a Ca2+dependent manner with cholesterol-rich lipid raft ...
M. Valapala, J. Vishwanatha
semanticscholar   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Assembly mechanism of fingolimod in lipid raft nanostructure domain [PDF]

BIO Web of Conferences
Fingolimod (FTY720) is an immunomodulatory drug used to treat multiple sclerosis (MS), belonging to S1P receptor modulators. It regulates the function of immune cells by acting on the Sphingosine-1-phosphate receptor (S1P receptor), thereby achieving the
Wu Huan
doaj   +1 more source