Results 161 to 170 of about 34,012 (255)

Combined Effects of Atorvastatin and Glucose Deprivation on Metabolic Stress and Lipid-Raft Disruption in Glioblastoma and Breast Cancer Cells. [PDF]

Pharmaceutics
Alshaer W, Ijjeh Y, Alsarayreh N, Alqudah DA, Rifai A, Abu-Siniyeh A, Alsalem M.   +6 more
europepmc   +1 more source

Let There be Light! Light as an Engine and Regulator in Synthetic Cells

Angewandte Chemie International Edition, Volume 65, Issue 24, 8 June 2026.
Cells are out‐of‐equilibrium systems that regulate their spatiotemporal features. In biomimetic synthetic cells, light offers a unique way for energizing and regulating events in space and time. This review explores the implementation of light‐responsive tools in synthetic cells to replicate biological functions and enable new bioinspired behaviors ...
Matthew E. Allen, Saskia Frank, Mehaiarii Louis, Atreyee Saha, Ali Heidari, Seraphine V. Wegner   +5 more
wiley   +1 more source

25-hydroxysterol mitigates microgravity-induced retinal damage by suppressing microglial inflammation through disrupting lipid raft formation. [PDF]

NPJ Microgravity
Lee JH, Kim DY.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Elaidic acid drives cellular senescence and inflammation via lipid raft-mediated IL-1R signaling. [PDF]

iScience
Kojima R, Hirata Y, Ashida R, Takahashi M, Matsui R, Hama K, Watanabe A, Takita R, Sato E, Abe T, Yokoyama K, Noguchi T, Matsuzawa A.   +12 more
europepmc   +1 more source

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, Volume 15, Issue 24, 25 June 2026.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Artesunate Ameliorates SLE Atherosclerosis Through PPARγ-Driven Cholesterol Efflux Restoration and Disruption of Lipid Raft-Organized TLR9/MyD88 Signaling Pathway. [PDF]

Biomolecules
Zhang M, Pan X, He Y, Sun K, Wang Z, Tian W, Qiu H, Wang Y, Wen C, Chen J.   +9 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Cholesterol homeostasis and lipid raft dynamics at the basis of tumor-induced immune dysfunction in chronic lymphocytic leukemia. [PDF]

Cell Mol Immunol
Jacobs CF, Peters FS, Camerini E, Cretenet G, Rietveld J, Schomakers BV, van Weeghel M, Hahn N, Verberk SGS, Van den Bossche J, Langeveld M, Kleijwegt F, Eldering E, Zelcer N, Kater AP, Simon-Molas H.   +15 more
europepmc   +1 more source

Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Electrical stimulation (ESTIM) enhances vasculature formation in engineered human tissues. In 3D endothelial‐fibroblast constructs, conditioning with ESTIM promotes the formation of dense and highly branched networks that rapidly anastomose with mouse vasculature when implanted in vivo. Vessels formed under ESTIM are importantly functionally perfusable.
Katarzyna A. Grzelak, Ashley D. Westerfield, Vardhman Kumar, Kasturi Chakraborty, Navaneeth Krishna Rajeeva Pandian, Christopher S. Chen, Sangeeta N. Bhatia   +6 more
wiley   +1 more source