Results 171 to 180 of about 639,057 (242)

Skeletal Muscle–Derived Extracellular Vesicles During Eccentric and Concentric Exercise Promote Muscle Regeneration After Injury

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Skeletal muscle injuries significantly impair mobility and function, yet effective therapeutic interventions remain limited. Both eccentric exercise (EE) and concentric exercise (CE) promote muscle repair, but the underlying mechanisms are not fully understood.
Yining Zhou, Xiaoyan Shao, Pan Zhang, Jiaquan Lin, Xiang Chen, Xueying An, Zhuoying Jiang, Haosheng Wang, Depeng Fang, Yansi Xian, Bin Liu, Tao Shen, Ying Chen, Keran Li, Hongpeng Liu, Ying Li, Qing Jiang, Baosheng Guo   +17 more
wiley   +1 more source

The CRABP2–MDK Signaling Axis Promotes Lung Adenocarcinoma (LUAD) Progression and Highlights Prognostic Biomarkers

Molecular Carcinogenesis, Volume 65, Issue 10, Page 1163-1182, October 2026.
ABSTRACT Lung cancer is the leading cause of cancer‐related mortality worldwide, with LUAD being characterized by high incidence and mortality rates. Despite the use of various treatments, including surgery, chemotherapy, immunotherapy, and molecular targeted therapy, the prognosis in LUAD patients remains unfavorable.
Jingshun Zhang, Cui Zhang, Guopeng Jiang, Xia Liu, Yifan Li, Fuman Wang, Xuefei Sun, Peidao Sun   +7 more
wiley   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Dapagliflozin Attenuates NKCC2 Protein Expression and Alleviates Diabetic Kidney Disease in Salt Loaded‐Hypertensive Diabetic Db/Db Mice

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad, Niharika Bala, Arooba Illyas, Amir Kazory, Indra Chandrasekar, Abdel A. Alli   +5 more
wiley   +1 more source

The Role of EVs in the Aging Hematopoietic System

Aging Cell, Volume 25, Issue 10, October 2026.
Extracellular vesicles from aged bone marrow carry pro‐inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles therefore represent both a readout of hematopoietic aging and a potential therapeutic route.
Esra G. Kosebent, Nathalie Havranek, Karoline Kollmann, Kristina Kirschner, Eszter Doma, Kavya Gupta   +5 more
wiley   +1 more source

The Binding of Fibroblast Growth Factor 23 (FGF23) to FGF Receptor‐αKlotho Complex Increases Sinoatrial Electrical Activity

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim This study aims to investigate whether the Fibroblast Growth Factor 23 (FGF23) modulates the electrical activity of sinoatrial (SAN) cells. The canonical function of FGF23 is to regulate body phosphorus and calcium homeostasis by activating the FGF1 receptors (FGFR1)/α‐Klotho complex in the kidney and parathyroid glands.
Giorgia Bertoli, Patrizia Benzoni, Serena Canzolino, David Molla, Raffaella Milanesi, Chiara Piantoni, Makoto Kuro‐o, Carmen Delgado, Gema Ruiz‐Hurtado, Mirko Baruscotti, Annalisa Bucchi   +10 more
wiley   +1 more source

Ethanolamine plasmalogens increase luteinising hormone pulsatility and are associated with GPR61 expression in bovine gonadotrophin‐releasing hormone neurons

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Ethanolamine plasmalogens increased LH pulse frequency. GPR61 was expressed in GnRH neurons and gonadotrophs, suggesting a role in neuroendocrine regulation. Ethanolamine plasmalogens (EPls), but not choline plasmalogens (CPls), may act via GPR61 expressed in GnRH neurons in the preoptic area and in anterior pituitary gonadotrophs.
Hiroya Kadokawa, Tomoaki Kubo, Kana Kobayashi, Denis Karani Wanjiru, Yvan Bienvenu Niyonzima   +4 more
wiley   +1 more source

Exploring the significance of Kenya's indigenous and emerging blue foods for sustainable aquaculture development. A review

Journal of the World Aquaculture Society, Volume 57, Issue 5, October 2026.
Abstract Kenya's aquaculture sector is at a pivotal stage, transitioning from a historical reliance on Nile tilapia and African catfish toward a more diversified production portfolio that integrates indigenous and emerging freshwater and marine species. This shift is increasingly recognized as essential to enhance climate resilience, food security, and
Jonathan Munguti, Mavindu Muthoka, Domitila Kyule, Esther Magondu, Kevin Obiero, Jimmy Mboya, Menaga Meenakshisundaram, Tanga M. Chrysantus, Gerald Kwikiriza, Francis K. Njonge   +9 more
wiley   +1 more source

Biofloc‐based aquaculture: From monoculture to integrated systems

Journal of the World Aquaculture Society, Volume 57, Issue 5, October 2026.
Abstract The demand for high‐quality protein has been growing in recent years, led by population growth. The development of aquaculture has been considered one of the solutions to ensure food security worldwide. New farming technologies have been promoted to increase productivity and, at the same time, minimize environmental impacts.
Mohammad Hossein Khanjani, Otávio Augusto Lacerda Ferreira Pimentel, Soibam Khogen Singh, Luis Henrique da Silva Poersch, Felipe Boéchat Vieira, Gabriella do Vale Pereira, Gholamreza Ghaedi, Alireza Mohammadi, Saeed Hajirezaee, Alireza Ghaedi, Maurício Gustavo Coelho Emerenciano   +10 more
wiley   +1 more source