Results 151 to 160 of about 34,012 (255)

HaloTag Fusion Enables Dynamic Analysis of Prion Protein Biosynthesis, Turnover, and Misfolding

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Prion protein (PrP) misfolding underlies fatal neurodegenerative diseases. We developed a HaloTag‐based PrP fusion enabling spatiotemporal labeling of distinct PrP populations in living cells. This system recapitulates native PrP biology, reveals early misfolding events in disease‐associated mutants, and allows mechanistic interrogation of PrP‐lowering
Antonio Masone, Eleonora Busani, Roberto Chiesa   +2 more
wiley   +1 more source

The role of RNA structural motifs in RNA-lipid raft interaction. [PDF]

Sci Rep
Mańka R, Sapoń K, Zaziąbło J, Janas T, Czogalla A, Janas T.   +5 more
europepmc   +1 more source

Epileptiform activity influences theta-burst induced LTP in the adult hippocampus: a role for synaptic lipid raft disruption in early metaplasticity? [PDF]

Front Cell Neurosci, 2023
Carvalho-Rosa JD, Rodrigues NC, Silva-Cruz A, Vaz SH, Cunha-Reis D.   +4 more
europepmc   +1 more source

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle, Fabio Lolicato, Carmelo Tempra, Martina Pannuzzo, Michele F. M. Sciacca, Danilo Milardi, Carmelo La Rosa   +6 more
wiley   +1 more source

Lipid raft proteomics identify endothelial myosin-9 (MYH9) as a regulator of low-density lipoprotein transcytosis and atherosclerosis. [PDF]

Proc Natl Acad Sci U S A
Jang E, Ghaffari S, Henry A, Wen G, Ho TWW, Cheng WH, Lyu Y, Wei K, Wang C, Romanoski CE, Wang Y, Cybulsky MI, Lee WL.   +12 more
europepmc   +1 more source

Membrane lipid raft homeostasis is directly linked to neurodegeneration. [PDF]

Essays Biochem, 2021
Moll T, Marshall JNG, Soni N, Zhang S, Cooper-Knock J, Shaw PJ, Shaw PJ.   +6 more
europepmc   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Who's in, who's out? Re-evaluation of lipid raft residents. [PDF]

J Neurochem, 2021
Mlinac-Jerkovic K, Ilic K, Zjalić M, Mandić D, Debeljak Ž, Balog M, Damjanović V, Maček Hrvat N, Habek N, Kalanj-Bognar S, Schnaar RL, Heffer M.   +11 more
europepmc   +1 more source

Targeting Fatty Acid Synthase With Berberine Promotes IL‐10 Production in Macrophages and Prevents Relapse in a Murine Colitis Model

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Berberine enhances IL‐10 production in macrophages via FASN‐dependent mechanisms, thereby promoting epithelial repair and preventing colitis relapse. Created with BioRender.com. ABSTRACT Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by alternating periods of remission and relapse.
Shusaku Hayashi, Yudai Ogawa, Nonoka Wakabayashi, Koga Tokuyama, Makito Oku, Takeshi Yamamoto, Shinichi Kato, Asma Nusrat, Makoto Kadowaki   +8 more
wiley   +1 more source

Es werde Licht! Licht als Antrieb und Regulator in synthetischen Zellen

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
Zellen sind Systeme außerhalb des Gleichgewichts, die ihre Eigenschaften in Raum und Zeit regulieren. In biomimetischen synthetischen Zellen bietet Licht eine einzigartige Möglichkeit, Vorgänge räumlich und zeitlich anzutreiben und zu kontrollieren.
Matthew E. Allen, Saskia Frank, Mehaiarii Louis, Atreyee Saha, Ali Heidari, Seraphine V. Wegner   +5 more
wiley   +1 more source