Results 191 to 200 of about 639,057 (242)

Mechanisms and Predisposing Conditions for Statin‐Induced New‐Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley   +1 more source

From Temperature Fluctuations to Precise Control: Biochemical Techniques Integrated Digital‐Intelligent Technology for Vegetable Preservation

open access: yesFuture Postharvest and Food, Volume 3, Issue 3, Page 296-319, September 2026.
The physiological effects and molecular responses of postharvest vegetables to temperature fluctuations, and multi‐technology integration strategies for maintaining postharvest vegetable quality. ABSTRACT Vegetables are indispensable agricultural products in the human diet. With the continuous growth of vegetable production and consumption, postharvest
Shuaishuai Dai   +4 more
wiley   +1 more source

Bushen Huatan Formula Ameliorates Early Chronic Low‐Grade Inflammation in Obese PCOS Via the TLR4/NF‐κB Signaling Pathway: An Integrated Network Pharmacology and Experimental Study

open access: yesImmunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This study used an integrated network pharmacology and experimental strategy to investigate how Bushen Huatan Formula (BHF) mitigates early‐stage chronic low‐grade inflammation in obese polycystic ovary syndrome (PCOS). Methods Candidate components and targets of BHF were retrieved from the TCMSP database, and protein–protein ...
Jianing Zhang   +6 more
wiley   +1 more source

Molecularly imprinted polymers based electrochemical sensors for biomarker detection in biofluids

open access: yesInfoScience, Volume 3, Issue 3, September 2026.
This review systematically summarizes the evolution of molecularly imprinted polymer electrochemical sensors from bulk structures to advanced nano‐imprinted architectures. It decouples the complex matrix effects of clinical biofluids and evaluates interfacial engineering strategies for anti‐biofouling.
Tianrui Zhu   +7 more
wiley   +1 more source

Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation

open access: yesiNew Medicine, Volume 2, Issue 3, September 2026.
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng   +3 more
wiley   +1 more source

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

open access: yesInterdisciplinary Medicine, Volume 4, Issue 5, September 2026.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou   +3 more
wiley   +1 more source

Neuronal Apoptotic Bodies Facilitate Japanese Encephalitis Virus Infection and Pathogenicity

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Japanese encephalitis (JE) caused by Japanese encephalitis virus (JEV) infection remains one of the major types of viral encephalitis. The mechanisms underlying JEV infection and pathogenesis have not been fully elucidated, resulting in the absence of specific therapies for JE. Neuronal apoptosis is a well‐established outcome of JEV infection;
Chuan Zeng   +9 more
wiley   +1 more source

The Origin of Lipid Rafts

Biochemistry, 2020
The time-averaged lateral organization of the lipids and proteins that make up mammalian cell membranes continues to be the subject of intense interest and debate. Since the introduction of the fluid mosaic model almost 50 years ago, the "lipid raft hypothesis" has emerged as a popular concept that has captured the imagination of a large segment of the
openaire   +2 more sources

Imaging Lipid Rafts

Journal of Biochemistry, 2005
Lipid rafts are plasma membrane microdomains enriched in sphingolipids and cholesterol. These domains have been suggested to serve as platforms for various cellular events, such as signaling and membrane trafficking. However, little is known about the distribution and dynamics of lipids in these microdomains.
Reiko, Ishitsuka   +2 more
openaire   +2 more sources

Lipid rafts in psychiatry

2019
Lipid microenvironments in the plasma membrane are known to influence many signal transduction pathways. Several of those pathways are critical for both the etiology and treatment of depression. Further, several signaling proteins are modified, covalently, by lipids, a process that alters their interface with the microenvironments mentioned above. This
Nathan H, Wray, Mark M, Rasenick
openaire   +2 more sources

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