Results 211 to 220 of about 64,062 (299)

Jurkat T-Cell Antigen-Independent Elimination of PMA-Activated Neuroblastoma Cells Is Triggered by CCL2/CCR2, Depends Upon Lipid Raft LFA1/ICAM1 Immune Synapses, Is Mediated by m-TRAIL and Is Augmented by the TrkAIII Oncoprotein. [PDF]

Int J Mol Sci
Sbaffone M, Martelli I, Cipriani P, Farina AR, Cappabianca LA, Mackay AR.   +5 more
europepmc   +1 more source

SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold‐Mediated Regulation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, serves as a molecular hub in human diseases by integrating cytoskeletal remodelling, signal transduction and RNA metabolic regulation. This study systematically analyses SORBS2's molecular features,
Qiwei Jia, Yong Zhang
wiley   +1 more source

Cholesterol homeostasis and lipid raft dynamics at the basis of tumor-induced immune dysfunction in chronic lymphocytic leukemia. [PDF]

Cell Mol Immunol
Jacobs CF, Peters FS, Camerini E, Cretenet G, Rietveld J, Schomakers BV, van Weeghel M, Hahn N, Verberk SGS, Van den Bossche J, Langeveld M, Kleijwegt F, Eldering E, Zelcer N, Kater AP, Simon-Molas H.   +15 more
europepmc   +1 more source

Host RhoA Signaling Controls Filamentous vs. Spherical Morphogenesis and Cell-to-Cell Spread of RSV via Lipid Raft Localization: Host-Directed Antiviral Target. [PDF]

Microorganisms
Pastey MK, McCurdy LH, Graham BS.
europepmc   +1 more source

Lactobacillus Protects Against Chronic Suppurative Otitis Media via Modulating RFTN1/ Lipid Raft /TLR4-Mediated Inflammation. [PDF]

Biologics
Liu Z, Zhang F, Jia F, Li S, Jiang C, Ruan B, Long R.   +6 more
europepmc   +1 more source

Characterization of the Human Blood Group Glycosyltransferases GTA and GTB for the Synthesis of Blood Group Antigens

Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.
This study presents the highly efficient heterologous production of the human blood group glycosyltransferases GTA/R176A and GTB, along with their comprehensive biochemical and kinetic characterization. Tailored enzyme cascades, involving the bacterial fucosyltransferase FutC and GTA or GTB, generate milligram quantities of various blood group ABH ...
Katja Pöstges, Philip Palm, Kai P. Hussnaetter, Eliška Filipová, Helena Pelantová, Lucie Petrásková, Pavla Bojarová, Vladimír Křen, Lothar Elling   +8 more
wiley   +1 more source

N-(3-Oxododecanoyl)-Homoserine Lactone Induces Intestinal Barrier Damage in Piglets via the Lipid Raft-Mediated Apoptosis Pathway. [PDF]

Vet Sci
Yang Y, Zhang X, Yang J, Wu Z, Li J, Song R, Meng C, Zhu G.   +7 more
europepmc   +1 more source

Molecular Engineering of the Helminth TGF‐β Mimetics, TGM1 and TGM4, Reveals a Novel Antagonist of TGF‐β Signaling in Fibroblasts

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
The helminth TGF‐β mimic TGM4 activates SMAD signaling in macrophages and T cells through canonical TGF‐β receptors and the CD44 co‐receptor, through Domains 1–5 (D1‐5). In fibroblasts, which express lower levels of CD44, TGM4 binds but does not transduce a signal; furthermore, it inhibits activation by agonist ligands such as TGF‐β itself, in a manner
Kyle T. Cunningham, Claire Ciancia, Tiffany Campion, Maarten van Dinther, Nadia Davis, Anja Duffy, Anna L. L. Heawood, Luke Power, Anna Sanders, Shashi P. Singh, Danielle J. Smyth, Elizabeth Thompson, Ruby White, Andrew P. Hinck, Peter ten Dijke, Rick M. Maizels   +15 more
wiley   +1 more source

The transmembrane domain of the desmosomal cadherin desmoglein-1 governs lipid raft association to promote desmosome adhesive strength. [PDF]

Mol Biol Cell
Zimmer SE, Giang W, Levental I, Kowalczyk AP.   +3 more
europepmc   +1 more source

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, Volume 36, Issue 28, 7 April 2026.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source