A P-glikoprotein membrán mikrokörnyezete és működésének gátolhatósága modulátor és antitest együttes alkalmazásával = P-glycoprotein membrane microenviroment and inhibition of pumping by the combined application of modulators and specific antibody [PDF]
, 2009 A multidrog rezisztencia hátterében gyakran a P-glikoprotein (Pgp) pumpa működése áll, melynek gátlására jelentős erőfeszítések történnek világszerte. Az UIC2 antitest a fehérjét katalitikus ciklusa egy fázisában ismeri fel, és ott blokkolja.
Bacsó, Zsolt +3 more
core
Conditions for extreme sensitivity of protein diffusion in membranes to cell environments
, 2006 We study protein diffusion in multicomponent lipid membranes close to a rigid substrate separated by a layer of viscous fluid. The large-distance, long-time asymptotics for Brownian motion are calculated using a nonlinear stochastic Navier-Stokes ...
Baumgart +6 more
core +2 more sources
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction [PDF]
, 2016 Anthony Cruz +15 more
openalex +1 more source
Pediatric Discovery, EarlyView.Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu +4 more
wiley +1 more source
The dipole potential correlates with lipid raft markers in the plasma membrane of living cells [PDF]
, 2017 Tamás Kovács +4 more
openalex +1 more source
Diverse reactivity of maleimides in polymer science and beyond
Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick +2 more
wiley +1 more source
Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease [PDF]
, 2014 Nicole T. Watt +2 more
openalex +1 more source
Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery
Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá +4 more
wiley +1 more source
Small, EarlyView.Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source