Results 41 to 50 of about 75,080 (297)

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytess⃞

Journal of Lipid Research, 2007
Although reverse cholesterol transport from peripheral cell types is mediated through plasma membrane microdomains termed lipid rafts, almost nothing is known regarding the existence, protein/lipid composition, or structure of these putative domains in ...
Barbara P. Atshaves, Avery L. McIntosh, H. Ross Payne, Adalberto M. Gallegos, Kerstin Landrock, Nobuyo Maeda, Ann B. Kier, Friedhelm Schroeder   +7 more
doaj   +1 more source

Lipid rafts and Alzheimer’s disease: protein-lipid interactions and perturbation of signalling

Frontiers in Physiology, 2012
Lipid rafts are membrane domains, more ordered than the bulk membrane and enriched in cholesterol and sphingolipids. They represent a platform for protein-lipid and protein-protein interactions and for cellular signalling events.
David A. Hicks, Natalia N Nalivaeva, Natalia N Nalivaeva, Anthony J Turner   +3 more
doaj   +1 more source

Single virus tracking of Ebola virus entry through lipid rafts in living host cells

Biosafety and Health, 2020
Ebola virus (EBOV) is one of the most pathogenic viruses in humans which can cause a lethal hemorrhagic fever. Understanding the cellular entry mechanisms of EBOV can promote the development of new therapeutic strategies to control virus replication and ...
Cong Jin, Bin Che, Zhengyuan Guo, Chuan Li, Yang Liu, Wei Wu, Shiwen Wang, Dexin Li, Zongqiang Cui, Mifang Liang   +9 more
doaj   +1 more source

Lipid rafts and membrane traffic [PDF]

FEBS Letters, 2007
Membrane rafts are regions of increased lipid acyl chain order that differ in their lipid and protein composition from the surrounding membrane. By providing an additional level of compartmentalization they have been proposed to serve many functions in cellular signal transduction and trafficking. We will review their potential involvement in different
Hanzal-Bayer, M. F., Hancock, J. F.
openaire   +3 more sources

Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles [PDF]

, 2013
We previously reported that the incorporation of tissue factor (TF) into cell-derived microvesicles (MVs) is regulated by the phosphorylation of the cytoplasmic domain of TF.
Collier, Mary E. W., Ettelaie, Camille, Maraveyas, Anthony   +2 more
core   +1 more source

A simplified method for the preparation of detergent-free lipid rafts

Journal of Lipid Research, 2005
Lipid rafts are small plasma membrane domains that contain high levels of cholesterol and sphingolipids. Traditional methods for the biochemical isolation of lipid rafts involve the extraction of cells with nonionic detergents followed by the separation ...
Jennifer L. Macdonald, Linda J. Pike
doaj   +1 more source

Clostridium innocuum, an emerging pathogen that induces lipid raft-mediated cytotoxicity

Virulence, 2023
Clostridium innocuum is an emerging spore-forming anaerobe that is often observed in Clostridioides difficile-associated inflammatory bowel disease (IBD) exacerbations. Unlike C. difficile, C. innocuum neither produces toxins nor possesses toxin-encoding
Hui-Yu Wu, Chia-Jung Kuo, Chia-Huei Chou, Mao-Wang Ho, Chyi-Liang Chen, Tsui-Shan Hsu, Ying-Chu Chen, Chuan Chiang-Ni, Yi-Ywan M. Chen, Cheng-Hsun Chiu, Chih-Ho Lai   +10 more
doaj   +1 more source

Editorial: Membrane lipids in T cell functions [PDF]

, 2018
Plasma membrane lipids play essential roles in regulating T cell signaling, differentiation, and effector functions. The major lipid species in the plasma membrane are glycerophospholipids, sphingolipids, and sterol lipids.
Tuosto, Loretta, Xu, Chenqi
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source