Results 31 to 40 of about 632,056 (157)

REACTIVE OXYGEN SPECIES, CELLULAR REDOX SYSTEMS AND APOPTOSIS

Free Radical Biology & Medicine, 2010
Reactive oxygen species (ROS) are products of normal metabolism and xenobiotic exposure, and depending on concentrations, ROS can be beneficial or harmful to cells and tissues.
M. Circu, T. Aw
semanticscholar   +1 more source

The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer

Frontiers in Oncology, 2022
Ferroptosis is an iron-dependent cell death process characterized by excessive accumulation of reactive oxygen species and lipid peroxidation. The elucidation of ferroptosis pathways may lead to novel cancer therapies.
Kun Ke, Kun Ke, Li Li, Li Li, Chao Lu, Qicong Zhu, Yuanyu Wang, Yiping Mou, Yiping Mou, Huiju Wang, Huiju Wang, Weiwei Jin, Weiwei Jin   +12 more
doaj   +1 more source

Reactive oxygen species‐induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging

Aging Cell, 2019
Aging is a major risk factor for many chronic diseases due to increased vulnerability to external stress and susceptibility to disease. Aging is associated with metabolic liver disease such as nonalcoholic fatty liver.
Eunhui Seo, Hwansu Kang, Hojung Choi, Woohyuk Choi, H. Jun   +4 more
semanticscholar   +1 more source

Molecular dynamic simulations of oxidized skin lipid bilayer and permeability of reactive oxygen species

Scientific Reports, 2019
Lipid peroxidation by reactive oxygen species (ROS) during oxidative stress is non-enzymatic damage that affects the integrity of biological membrane, and alters the fluidity and permeability. We conducted molecular dynamic simulation studies to evaluate
D. Yadav, Surendra Kumar, E. Choi, S. Chaudhary, Mi-hyun Kim   +4 more
semanticscholar   +1 more source

The Relationship Between Reactive Oxygen Species and Endothelial Cell Metabolism

Frontiers in Chemistry, 2020
Cardiovascular disease (CVD) has been the leading cause of death for many decades, highlighting the importance of new research and treatments in the field.
Raid Alhayaza, E. Haque, Catherine Karbasiafshar, F. Sellke, M. Abid   +4 more
semanticscholar   +1 more source

Epilipidomics reveals lipid fatty acid and headgroup modification in gas plasma-oxidized biomembranes

Redox Biology
Lipids, possessing unsaturated fatty acid chains and polar regions with nucleophilic heteroatoms, represent suitable oxidation targets for autologous and heterologous reactive species.
Johanna Striesow, Zahra Nasri, Thomas von Woedtke, Sander Bekeschus, Kristian Wende   +4 more
doaj   +1 more source

The role of nitric oxide signaling in food intake; insights from the inner mitochondrial membrane peptidase 2 mutant mice

Redox Biology, 2013
Reactive oxygen species have been implicated in feeding control through involvement in brain lipid sensing, and regulating NPY/AgRP and pro-opiomelanocortin (POMC) neurons, although the underlying mechanisms are unclear.
Changjie Han, Qingguo Zhao, Baisong Lu
doaj   +1 more source

Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2

Nature Communications, 2020
The protein Insig-2 negatively regulates lipid biosynthesis and is short-lived in liver cells but stable in muscle cells. Here, the authors show that in muscle cells producing reactive oxygen species, there is increased oxidation compared to ...
Zhang-Sen Zhou, Mei-Xin Li, Jie Liu, Hengwu Jiao, Jing-Ming Xia, Xiong-Jie Shi, Huabin Zhao, Liping Chu, Jingrong Liu, Wei Qi, Jie Luo, Bao-Liang Song   +11 more
doaj   +1 more source

Antioxidant activity of polysaccharides extracted from Lentinus edodes mycelia and their protective effects on INS-1 cells

Bioscience Journal, 2016
The disruption of the delicate balance between the generation of reactive oxygen species (ROS) and antioxidant scavenging systems can lead to many health problems.
Jianli Liu, Weiyu Wang, Hui Yu, Xiangyu Cao, Ying Wang, Meijia Liu, Xiao Yan, Hongsheng Liu   +7 more
doaj   +3 more sources

Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells

Acta Biochimica et Biophysica Sinica, 2023
Ferroptosis is a new form of nonapoptotic cell death closely associated with glutathione (GSH) peroxidase 4 inhibition and/or GSH depletion, resulting in the accumulation of cellular iron and lipid peroxides.
Hou Ming-Jie, Wang Pan, Zhu Bao Ting
doaj   +1 more source