Results 141 to 150 of about 848,065 (307)

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

PHR1-like 7 and phosphatidic acid oppositely regulate TAG degradation and seed oil accumulation in Arabidopsis

Plant Communications
Triacylglycerol (TAG) degradation plays an important role in seed oil accumulation, but how this catabolic process is transcriptionally regulated in developing seeds remains poorly understood.
Shan Tang, Wenhao Shen, Shuaibing Yao, Sang-Chul Kim, Jianwu Li, Bao Yang, Xuemin Wang   +6 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Membrane rafts in T cell activation: A spotlight on CD28 costimulation [PDF]

, 2017
Abrahamsen, Acuto, Ambach, Asanov, August, Bi, Billadeau, Bjørgo, Byrum, Chiang, Chuang, Comrie, Davis, Dennehy, Dupré, Dustin, Eggeling, Esensten, Fischer, Garçon, Gaus, Golub, Gri, Harada, Harder, Harding, Hayashi, Head, Holdorf, Hui, June, Kabouridis, Kallikourdis, Kamphorst, Kenworthy, Kim, Kong, Krawczyk, Kündig, Lasserre, Ledbetter, Lee, Liang, Lichtenberg, Lingwood, Liu, Marengère, Martin, Mayor, Monks, Muscolini, Muscolini, Muscolini, Nakamura, Owen, Paccani, Pagès, Pike, Pike, Pike, Pizzo, Porciello, Porciello, Pralle, Raab, Raab, Raychaudhuri, Resh, Roncagalli, Round, Ruppelt, Russell, Salazar-Fontana, Salomon, Sanchez-Lockhart, Schütz, Shahinian, Sherman, Simons, Simons, Subczynski, Tavano, Tavano, Varma, Varshney, Villalba, Villalba, Viola, Viola, Viola, Viola, von Haller, Watanabe, Yokosuka, Zhang, Zhang   +95 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

The Development of LAT1 Efflux Agonists as Mechanistic Probes of Cellular Amino Acid Stress

Biomolecules
Amino acid restriction induces cellular stress and cells often respond via the induction of autophagy. Autophagy or ‘self-eating’ enables the recycling of proteins and provides the essential amino acids needed for cell survival.
Vandana Sekhar, Houssine Ikhlef, Alexandra Bunea, Viet S. Nguyen, Johan Joo, Mukund P. Tantak, Holly Moots, Otto Phanstiel   +7 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Deciphering Complex Interactions in Bioactive Lipid Signaling. [PDF]

Molecules, 2023
Maccarrone M.
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source