Results 181 to 190 of about 848,065 (307)

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho-Epithelial Cells by Modulating Eicosanoid Lipid Signaling. [PDF]

Adv Sci (Weinh)
Gupta G, Bossart J, D'Almeida SM, de Luna LAV, Schwärzler C, Fu T, Ayala-Nunez V, Gogos A, Buljan M, Kissling VM, Flahaut E, Garcia M, Bussy C, Wick P, Buerki-Thurnherr T.   +14 more
europepmc   +1 more source

Lipid Signaling Requires ROS Production to Elicit Actin Cytoskeleton Remodeling during Plant Innate Immunity. [PDF]

Int J Mol Sci, 2022
Cao L, Wang W, Zhang W, Staiger CJ.
europepmc   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Editorial: Inflammation and lipid signaling in disease pathogenesis. [PDF]

Front Pharmacol
Patrignani P, Brüne B, Sala A, Minuz P, Steinhilber D.   +4 more
europepmc   +1 more source

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

DGKs in lipid signaling and disease intervention: structural basis, pathological mechanisms, and emerging therapeutic strategies. [PDF]

Cell Mol Biol Lett
Liu J, Ma J, Zhang Y, Li J, Yang Y, Yin P, Wan X, Ma S, Shang D.   +8 more
europepmc   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Functional regulation of macrophages by Ces1d-mediated lipid signaling in immunometabolism. [PDF]

Mol Metab
Shao LJ, Elizondo F, Gao F, Habib R, Li X, Pham K, Ysaguirre J, Elizondo M, Shirazi S, Eckel-Mahan KL, Hartig S, Wu H, Sun K.   +12 more
europepmc   +1 more source

LL‐37 Driven Phase Transition and Stacking in Oligolamellar Gram‐Negative Bacterial Membrane Models

Advanced Functional Materials, EarlyView.
This work establishes oligolamellar bacterial membrane models to investigate how LL‐37 disrupts the complex dual‐bilayer architecture of Gram‐negative bacteria. Combining SAXS, cryo‐TEM, electrophoretic mobility measurements, and coarse‐grained simulations, it reveals cardiolipin‐driven phase transitions leading to bicelle‐like structures and membrane ...
Bettina Tran, Diane C.A. Lima, Linda Sandblad, Madeleine Ramstedt, Thereza A. Soares, Stefan Salentinig   +5 more
wiley   +1 more source

Preparation of fatty acid solutions for investigating lipid signaling, metabolism, and lipid droplets. [PDF]

Protein Cell
Zhang S, Zhang M, Xu S, Fu X, Liao Q, Pan B, Cui L, Liu P.   +7 more
europepmc   +1 more source