Results 201 to 210 of about 564,255 (265)

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

HIF-3α/PPAR-γ Regulates Hypoxia Tolerance by Altering Glycolysis and Lipid Synthesis in Blunt Snout Bream (<i>Megalobrama amblycephala</i>). [PDF]

Int J Mol Sci
Jiang M, Huang J, Guo X, Fu W, Peng L, Wang Y, Liu W, Liu J, Zhou L, Xiao Y.   +9 more
europepmc   +1 more source

Age-Related Increases in IGFBP2 Increase Melanoma Cell Invasion and Lipid Synthesis. [PDF]

Cancer Res Commun
Alicea GM, Patel P, Portuallo ME, Fane ME, Wei M, Chhabra Y, Dixit A, Carey AE, Wang V, Rocha MR, Behera R, Speicher DW, Tang HY, Kossenkov AV, Rebecca VW, Wirtz D, Weeraratna AT.   +16 more
europepmc   +1 more source

Activation of the mTOR pathway enhances PPARγ/SREBP-mediated lipid synthesis in human meibomian gland epithelial cells. [PDF]

Sci Rep
Jun I, Choi YJ, Kim BR, Lee HK, Seo KY, Kim TI.   +5 more
europepmc   +1 more source

Creation of Genetically Modified Adipocytes for Tissue Engineering: Creatine Kinase B Overexpression Leads to Stimulated Glucose Uptake and Mitochondrial Potential Growth, but Lowered Lipid Synthesis. [PDF]

Life (Basel)
Michurina S, Beloglazova I, Agareva M, Alekseeva N, Parfyonova Y, Stafeev I.   +5 more
europepmc   +1 more source

Hyperacetylated histone H4 is a source of carbon contributing to lipid synthesis. [PDF]

EMBO J
Charidemou E, Noberini R, Ghirardi C, Georgiou P, Marcou P, Theophanous A, Strati K, Keun H, Behrends V, Bonaldi T, Kirmizis A.   +10 more
europepmc   +1 more source

Fatty aldehyde bisulfite adducts as a purification handle in ionizable lipid synthesis. [PDF]

RSC Adv
Atwood G, Purbiya S, Reid C, Smith B, Kaur K, Wicks D, Gaudet P, MacLeod KC, Vincent-Rocan JF.   +8 more
europepmc   +1 more source

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Synthesis of Lipidated Peptides

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Heinemann, I., Völkert, M., Waldmann, H.   +2 more
openaire   +3 more sources

Synthesis of Lipidated Proteins

Bioconjugate Chemistry, 2016
Protein lipidation is one of the major post-translational modifications (PTM) of proteins. The attachment of the lipid moiety frequently determines the localization and the function of the lipoproteins. Lipidated proteins participate in many essential biological processes in eukaryotic cells, including vesicular trafficking, signal transduction, and ...
Mejuch, T., Waldmann, H.
openaire   +3 more sources

Synthesis of Lipidated Peptides

2013
One of the main reasons of the high diversity and complexity of the human proteome compared to the human genome is the extensive work performed by the posttranslational machinery to incorporate numerous different functionalities on proteins. The covalent attachment of chemical moieties in proteins after translation is known as posttranslational ...
Rosi, F., Triola, G.
openaire   +3 more sources