Results 121 to 130 of about 17,356 (288)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Antimicrobial Peptides: Current Status, Mechanisms of Action, and Strategies to Overcome Therapeutic Limitations

Microorganisms
Antimicrobial peptides (AMPs), evolutionarily conserved components of the immune system, have attracted considerable attention as promising therapeutic candidates.
Seong Hwan Kim, Yu-Hong Min, Min Chul Park   +2 more
doaj   +1 more source

Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages.

The role of canonical autophagy in controlling Mycobacterium tuberculosis (Mtb), referred to as xenophagy, is understood to involve targeting Mtb to autophagosomes, which subsequently fuse with lysosomes for degradation.
Di Chen (15424), Maximiliano G Gutierrez (8133912), Antony Fearns (9045272)   +2 more
core   +1 more source

T0 treatment increases ABCA1 protein level and APOE lipidation.

, 2017
ABCA1, APOE and APOJ protein levels were determined by SDS-PAGE and APOE lipidation by Native PAGE. A, Representative image of ABCA1 protein level is shown above the graph. T0 significantly affected ABCA1 protein level. Analysis by two-way ANOVA shows no
Florent Letronne (3798238), Cody M. Wolfe (3798241), Anais Mounier (3798226), Hafsa Kamboh (3798229), Alexis Y. Carter (3798223), Iliya Lefterov (73826), Valerie L. Reeves (3798235), Nicholas F. Fitz (284717), Radosveta Koldamova (73830), Kyong Nyon Nam (3798232)   +9 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Is host lipidation of pathogen effector proteins a general virulence mechanism?

Frontiers in Cellular and Infection Microbiology, 2011
Stéphane eMéresse
doaj   +1 more source

Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes

, 2019
Covalent modification of LC3 and GABARAP proteins to phosphatidylethanolamine in the double-membrane phagophore is a key event in the early phase of macroautophagy, but can also occur on single-membrane structures. In both cases this involves transfer of
Simonsen, Anne, Anne Simonsen, Carlsson, Sven R, Lystad, Aif Hakon, Yoshimori, Tamotsu, Karlina J. Kauffman, Sven R. Carlsson, Carlsson, Sven R,, de la Ballina, Laura R., Lystad, Alf Håkon, Laura R. de la Ballina, Thomas J. Melia, Alf Håkon Lystad, Melia, Thomas J, Kauffman, Karlina J., Shanta Nag, Kauffman, Karlina J, Nag, Shanta, Rodriguez de la Ballina, Laura, Melia, Thomas J., Tamotsu Yoshimori   +20 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source