Results 201 to 210 of about 21,627 (236)

A Lipidomic Analysis Reveals Dynamic Changes of Polar Lipids for Oil Biosynthesis During Cotyledon Development in <i>Perilla frutescens</i>. [PDF]

Plants (Basel)
Liu X, Zhang J, Xu W, Du X, Yang D, Xu L, Zhang S, Gao T.   +7 more
europepmc   +1 more source

ACSL3 Promotes Hepatocellular Carcinoma Tumorigenesis and Correlates With JAK–STAT3 Signaling

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with limited therapies. Reprogrammed lipid metabolism, driven by upregulated de novo lipogenesis, is a key tumorigenic mechanism. The enzyme ACSL3 is strongly correlated with poor HCC prognosis, positioning it as a potential therapeutic target.
Melika Amelimojarad, Mandana Amelimojarad, Alireza Pourmahdian, Zhang Lu   +3 more
wiley   +1 more source

The Effect of Short-Term and High-Intensity Functional Circuit Training on Plasma Lipidome Profiles of People Living with and Without HIV. [PDF]

Metabolites
Yoshinaga MY, Faria FG, Chaves-Filho AB, Miyamoto S, Pithon-Curi TC, Bueno GC, Silva BF, Peres SB, de Moraes SMF.   +8 more
europepmc   +1 more source

Digital Biomarkers for Precision Early Detection of Lung Cancer: Integrating AI‐Driven Multi‐Omics Into Clinical Pathways

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Lung cancer remains the leading cause of cancer‐related mortality worldwide, highlighting the urgent need for earlier detection within real‐world screening and patient management pathways. Recent advances in multi‐omics technologies have created new opportunities for identifying biomarkers associated with early‐stage lung cancer ...
Fan Bu, Zhi‐Qiang Ling
wiley   +1 more source

Altered lipidomic and metabolomic status in cerebrospinal fluid of children with myelin oligodendrocyte glycoprotein antibody-associated disorder. [PDF]

Biochem Biophys Rep
Chong PF, Kajiwara K, Ueno Y, Akamine S, Torisu H, Kira R, Ohga S, Sakai Y.   +7 more
europepmc   +1 more source

Risk Factors and Prediction Model for Early‐Onset Immune‐Related Adverse Events in Pan‐Cancer Patients Undergoing Anti‐PD‐(L)1 Therapy: A Retrospective Study in a Tertiary‐Level Hospital

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Anti‐programmed death 1 (PD‐1) and anti‐programmed death ligand 1 (PD‐L1) immune checkpoint inhibitors (ICIs) have changed the treatment landscape of many advanced malignancies. However, immune‐related adverse events (irAEs) bring great challenges to clinical benefits. The prediction of irAEs is urgently demanded for early detection
Panpan Jiao, Lijuan Xue, Weijuan Tan, Quan Chen, Shan Lin, Min Song, Chunling Ma, Juan Zhan   +7 more
wiley   +1 more source

A Machine Learning Model Based on First-Trimester Lipidomic Signatures for Predicting Metabolic Pregnancy Complications. [PDF]

Int J Mol Sci
Tokareva A, Frankevich NA, Chagovets V, Derenko A, Lagutin V, Frankevich V, Sukhikh G.   +6 more
europepmc   +1 more source

Single‐cell sequencing for cancer precision medicine: From mechanism discovery to diagnosis and therapeutics

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Single‐cell sequencing overcomes bulk sequencing limitations, enabling high‐resolution multi‐omics analysis at the single‐cell level. It reveals tumour heterogeneity, identifying key subpopulations and tumour microenvironment interactions driving progression and resistance.
Yue Zhao, Hancong Li, Huanzuo Yang, Gongshuang Zhang, Xinyue Fu, Peiheng Li, Puxing He, Shuang Wu, Han Luo   +8 more
wiley   +1 more source

Multi-Omics Analysis Reveals Distinct Lipid Remodelling and Mitochondrial Stress in SH-SY5Y Cells Modelling Parkinson's Disease. [PDF]

Metabolites
Wang S, Ni Z, Wang G, Zhang J, Tan Y, Hong E, Wang Y, Chen H, Hou H, Hu Q.   +9 more
europepmc   +1 more source

GPR183‐mediated activation of PI3K is a potential biomarker for immunotherapy in lung cancer

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Anti‐PD1 treatment and PI3Kγ inhibition had remarkable therapeutic performance on CD4+ Tcm and CD4+ Tn in lung cancer through potential regulation of PI3K pathway with participation of GPR183. Abstract Background As one of commonly used immune checkpoint inhibition therapies, PD1 monoclonal antibodies exhibit a promising cancer immunotherapy approach ...
Ling Ye, Nannan Zheng, Fangming Liu, Huirong Fu, Yifei Liu, Ying Yang, Ruixue Qi, Duojiao Wu, Lin Shi, Dongli Song   +9 more
wiley   +1 more source