Lipids, EarlyView.ABSTRACT Although sphingolipids are key players in lipotoxicity and metabolic diseases, their response to bariatric surgery and their relation to metabolic improvement remain unclear. This pilot study investigated plasma sphingolipid remodeling after Roux‐en‐Y gastric bypass (RYGB) and its associations with clinical and biochemical markers of ...
Gabriela de Oliveira Lemos +3 more
wiley +1 more source
Targeted LC-MS/MS-based metabolomics and lipidomics on limited hematopoietic stem cell numbers
, 2022 Katharina Schönberger +3 more
openalex +1 more source
Lipids, EarlyView.ABSTRACT This study aimed to explore the differences of peripheral blood (PB) and bone marrow serum lipidomic profiles in severe aplastic anemia (SAA) patients and their significance in predicting earlier immunosuppressive therapy (IST) response. A cohort of 11 newly diagnosed SAA patients and 15 healthy controls were enrolled between June 2020 and ...
Zexing Sun +11 more
wiley +1 more source
A Perspective of Multi‐Reflecting TOF MS
Mass Spectrometry Reviews, EarlyView.ABSTRACT Time‐of‐flight mass spectrometry (TOF MS) excels in rapid and high‐sensitivity analysis, making it a cornerstone of analytical chemistry. But as sample complexity explodes in omics studies, so does the need for higher resolving power to ensure accurate results.
A. N. Verenchikov +3 more
wiley +1 more source
Is Lipid Metabolism of Value in Cancer Research and Treatment? Part I- Lipid Metabolism in Cancer
MetabolitesFor either healthy or diseased organisms, lipids are key components for cellular membranes; they play important roles in numerous cellular processes including cell growth, proliferation, differentiation, energy storage and signaling. Exercise and disease
Ala F. Nassar +10 more
doaj +1 more source
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Distinct plasma molecular profiles between early-onset and late-onset colorectal cancer patients revealed by metabolic and lipidomic analyses [PDF]
Shiqi Zhang +7 more
openalex +1 more source
Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids
Movement Disorders, EarlyView.Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley +1 more source
Metabolomic and lipidomic profiling of plasma in kidney stone patients: identification of potential biomarkers and therapeutic targets [PDF]
Ziyu Fang +15 more
openalex +1 more source
Serum lipidomics reveals phosphatidylethanolamine and phosphatidylcholine disorders in patients with myocardial infarction and post-myocardial infarction-heart failure [PDF]
, 2022 Jidong Rong +4 more
openalex +1 more source