Results 181 to 190 of about 32,392 (245)

Metabolic Signatures and Diagnostic Prediction Models for Coronary Artery Disease and Type 2 Diabetes Mellitus: Insights From an Exploratory Study

iNew Medicine, Volume 2, Issue 2, June 2026.
Metabolomic & lipidomic analysis reveals metabolic overlap between CAD & T2DM, highlighting 7 key metabolites as potential biomarkers. A predictive model based on these achieves high accuracy, potentially advancing precision medicine & metabolic insights.
Zhihua Wang, Meiming Su, Ying Li, Yapei Li, Shuo Chen, Ting Peng, Hans Strijdom, Jiangang Wang, Jianping Weng, Suowen Xu   +9 more
wiley   +1 more source

SMASH Imaging: A Serial Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Strategy for High-Resolution Imaging Facilitates Dual-Polarity and MS2 Spatial Lipidomics on a Single Tissue Section. [PDF]

Anal Chem
Uchino H, Tsugawa H, Arita M.
europepmc   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Targeted lipidomics between hPheo1 and SDHB KD cells reveal changes in bioactive lipids and PKC with polyamine pathway inhibition. [PDF]

Physiol Rep
Alli AA, Bala N, Xu Y, Denslow ND, Ghayee HK.   +4 more
europepmc   +1 more source

DAMP Laden Extracellular Vesicles From the Airways of Patients With Severe SARS‐CoV‐2 Respiratory Infection Compromise Inflammation and Cellular Metabolism

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Extracellular vesicles from severe COVID‐19 airways carry depleted miRNAs and elevated DAMPs, reprogramming monocytes toward senescence, impaired metabolism, and predominantly reduced cytokine responses. However, they drive excess IL‐8 production, amplifying neutrophil recruitment and dysfunctional inflammation across the respiratory tract.
April Rees, Oliver Richards, Molly E Raikes, Megan Chambers, Sophie G Reed, Ceri Battle, Hannah Toghill, Luke Newey, Tyler J Joseph, Haiyan An, Hui Zhang, Iain Perry, Jason Webber, Nicholas Jones, Catherine A Thornton   +14 more
wiley   +1 more source

Polystyrene Microplastics and Lead Co-Exposure Disturbed Hepatic Lipid Metabolism in C57BL/6 Mice. [PDF]

Metabolites
Gao B, Wei M, Zhao M, Xu W, Liu G, Shen W, Tu P, Shan J.   +7 more
europepmc   +1 more source

Impact of Isolation Techniques on the Content of Small Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT An important topic of discussion amongst the extracellular vesicle (EV) research field is which genetic materials are considered true constituents of EV cargo. What were once regarded as non‐EV components have now evolved to be potentially essential to EV composition, serving as key mediators in communication.
Yue Su, Kekoolani S. Visan, Sarah Voss, Marta Prieto‐Vila, Juntaro Matsuzaki, Jason Ying Kuen Chan, Judy Wai Ping Yam, Andreas Möller   +7 more
wiley   +1 more source

Curcumin Combined with Flaxseed Oil Modulates Lipid Metabolism in Hamsters Fed a High-Fat, High-Cholesterol Diet: Insights from Lipidomics. [PDF]

Nutrients
Wei PH, Huang CC, Hsu YJ, Lin YT, Loe PY, Chiu WC, Huang SY.   +6 more
europepmc   +1 more source

Extracellular Vesicles as Enabling Biomarkers for New Approach Methodologies to Support the US Food and Drug Administration Modernization Act 3.0

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT The FDA Modernization Act 3.0 represents a pivotal shift in biomedical research by formally removing the requirement for animal testing and enabling regulatory acceptance of New Approach Methodologies (NAMs). This transition creates an urgent need for robust, human‐relevant biomarkers that can anchor NAM‐generated data within regulatory ...
Andrew Rowland, Carl Kirkpatrick, A David Rodrigues, Uli Frevert, Franziska Haderk, David W Greening, Andrew J McLachlan, Ashley Hopkins, Fabrice Lucien, Rienk Nieuwland   +9 more
wiley   +1 more source

Comment: in-depth cerebrovascular lipidomics profiling for discovering novel biomarkers and mechanisms in moyamoya and intracranial atherosclerotic disease. [PDF]

Int J Surg
Siyuan H, Yi J.
europepmc   +1 more source