Results 191 to 200 of about 32,392 (245)

Inhibition of PLA2G15 Alleviates Palmitic Acid‐Induced Lysosomal Membrane Permeabilization in Human Nucleus Pulposus Cells During Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 2, June 2026.
LMP is responsible for lysosomal dysfunction in IDD. The lipid composition changes in the lysosomal membrane, mediated by PLA2G15, are the cause of LMP. The C/EBPα significantly promotes PLA2G15 expression under PA overload stress. Inhibition of PLA2G15 alleviates PA‐induced LMP by inhibiting the hydrolysis of lysosomal membrane phospholipids. ABSTRACT
Liqun Duan, Jiang Jiang, Shuangshuang Tu, Chuanfu Li, Yijun Dong, Yongjin Li, Wenzhi Zhang, Xi Chen   +7 more
wiley   +1 more source

Bovine Milk Polar Lipids: Lipidomics Advances and Functional Perspectives. [PDF]

Foods
Fappani G, Liu Z, Rochfort S, Rocchetti G.   +3 more
europepmc   +1 more source

Molecular Quantification of Fibrogenesis and Macrophage Activation Associate With Clinical Worsening in Patients With Cirrhosis

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Knowledge of the potential of biomarkers for monitoring clinical improvement, assessing trajectory or disease progression in advanced chronic liver disease is still insufficient. This study investigated biomarkers of fibrosis and macrophage activation over time in newly diagnosed patients with cirrhosis and their potential association with ...
Emilie Toft Skovgaard, Jens Peter Goetze, Thit Mynster Kronborg, Søren Møller, Henning Grønbæk, Holger Jon Møller, Morten Karsdal, Diana Julie Leeming, Nina Kimer   +8 more
wiley   +1 more source

The integration of plasma non-target metabolomics and lipidomics analysis for the discovery of global developmental delay/intellectual disability biomarkers. [PDF]

Front Cell Neurosci
Chen B, Chen S, Xiong J, Kessi M, Peng J, Yin F, He F.   +6 more
europepmc   +1 more source

Effect of Vitrification on Lipidomics in Porcine Cumulus-Oocyte Complexes After In Vitro Maturation. [PDF]

Cells
Huang X, He Z, Xiang D, Fu J, Li X, Jiang J, Quan G, Wu G, Jia B.   +8 more
europepmc   +1 more source

Integrating mass spectrometry-based multi-omic signatures of extracellular vesicles: from discovery to clinical translation. [PDF]

Clin Transl Immunology
Wijerathna-Yapa A, Aubert D, Kulasinghe A.   +2 more
europepmc   +1 more source

Plasma proteomics stratification identifies phospholamban R14del carriers at risk for disease progression. [PDF]

Cardiovasc Res
Deiman FE, Arslan T, de Brouwer R, Henry I, Löfgren L, Cavallin A, Michopoulos F, Nilsson R, Henricsson M, Ahlstrom C, Davidsson P, Bomer N, Grote Beverborg N, van der Meer P.   +13 more
europepmc   +1 more source

Plasma lipidomics, choline metabolites, and metabolic-associated steatotic liver disease (MASLD): A Coronary Artery Risk Development in Young Adults (CARDIA) study. [PDF]

PLoS One
Sprinkles JK, Qin Q, Steward C, Howard AG, Lulla A, Hullings AG, Carr JJ, Shaikh SR, Avery CL, North KE, Gordon-Larsen P, Meyer KA.   +11 more
europepmc   +1 more source