Results 191 to 200 of about 42,745 (295)

Mass Spectrometry-Based Lipidomics in Coffee: Linking Lipid Transformation to Flavor Formation and Quality Control. [PDF]

Foods
Wang Y, Wang X, Du P, Liu X.
europepmc   +1 more source

Lipidome [PDF]

, 2020
openaire   +1 more source

Targeted delivery of the CB2 receptor agonist JWH‐133 via VCAM‐1‐functionalised nanoparticles attenuates atherosclerosis and reveals sex‐specific therapeutic outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro, Lucía Martín‐Banderas, Josefa Álvarez‐Fuentes, María Dolores Herrera‐González   +3 more
wiley   +1 more source

A targeted lipidomics workflow for high-throughput phenotyping and mechanism-based in vitro hepatotoxicity studies. [PDF]

Toxicol In Vitro
Yen TH, Negi CK, Sakolish C, Baker ES, Rusyn I.   +4 more
europepmc   +1 more source

EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect

Cancer Science, EarlyView.
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu, Jingjia Chang, Zhiyong Li, Jin Wu, Pengfei Yu, Jingjing Zheng, Li Li, Jia Tao, Hao Wu, Yintao Li, Ming Liu   +10 more
wiley   +1 more source

A lipidomics roadmap: from basic research to societal challenges. [PDF]

Nat Commun
Fedorova M, Bendt AK, Bertrand-Michel J, Fiehn O, Godzien J, Goracci L, Gruber F, Guan XL, Han X, Holčapek M, Kuligowski J, Meikle PJ, Nepachalovich P, O'Donnell VB, Orešič M, Penkov S, Petrović S, Potapov A, Prabutzki P, Righetti L, Ruskovska T, Shevchenko A, Simons K, Spickett CM, Vvedenskaya O, Watts J, Wenk MR, Witting M, Xia Y, Yang B, Domingues MR.   +30 more
europepmc   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Insights into human cardiac lipid dynamics through comprehensive arteriovenous lipidomics. [PDF]

J Lipid Res
Bockus L, Chamoun N, Kassar A, Chahine Y, Haykal R, Li J, Wang D, O'Brien K, Djukovic D, Raftery D, Arany Z, Tian R, Sotoodehnia N, Akoum N.   +13 more
europepmc   +1 more source

Disentangling the effect of brain insulin resistance on brain health (BIR‐BrainHealth): Rationale and study protocol

Diabetic Medicine, EarlyView.
Abstract Aims Insulin signalling in the brain is crucial for systemic metabolic regulation and cognitive function. In some individuals, these effects are reduced, a phenomenon referred to as brain insulin resistance (BIR). This condition may contribute to the elevated risk of cognitive decline and dementia in diabetes, yet its prevalence, mechanisms ...
Sabrina Wangler, Peter Sørensen, Konni Kass, Nicole Jaqueline Jensen, Mark Bitsch Vestergaard, Julia Hummel, Ronja Völk, Julie Christine Antvorskov, Flemming Pociot, Jørgen Rungby, Martin Heni, Henrik Bo Wiberg Larsson   +11 more
wiley   +1 more source

Multi-Omics Insights into Chronic Rhinosinusitis with Nasal Polyps: A Review of Lipidomics, Proteomics, and Transcriptomics. [PDF]

J Inflamm Res
Wang S, Ma K, Sun L, Li P, Ma L.
europepmc   +1 more source