Results 221 to 230 of about 51,608 (289)

The SIMPLIFY Protocol: A Monophasic Extraction System Suitable for Exposomics, Metabolomics, Lipidomics, and Proteomics Research. [PDF]

Anal Chem
Nguyen AH, Castro-Alves V, Holmström Flores E, Barbosa JMG, Kråkström M, Reinivuori P, Kauko O, Dickens A, Orešič M, Hyötyläinen T.   +9 more
europepmc   +1 more source

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, Volume 13, Issue 25, 4 May 2026.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Discriminative Plasma Lipidomic Signatures of Dementia with Lewy Bodies and Alzheimer's Disease: A Targeted Mass Spectrometry and Machine Learning Approach. [PDF]

Neuropsychiatr Dis Treat
Wen L, Zhang Y, Nie Y, Shen H, Qin Q, Qu M.   +5 more
europepmc   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

LipidLocator: an open source Shiny web application for spatial lipidomics. [PDF]

Bioinform Adv
Arora P, Isfort S, Kirschke N, Masoodi M, Mercader N.   +4 more
europepmc   +1 more source

Pre‐analytical guidelines for blood and CSF Biomarkers 2025: Recommendations from the NACC ADRC Biofluid Biomarker Best Practices Workgroup

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The Biofluid Biomarkers Best Practices Workgroup of the National Alzheimer's Coordinating Center–Alzheimer's Disease Research Center (ADRC) Biomarker Core Steering Committee was convened to update pre‐analytical handling guidelines for biofluid biomarkers, focusing on cerebrospinal fluid (CSF) and blood.
Timothy E. Van Meter, Edward N. Wilson, Fanny Elahi, Robert A. Rissman, Argentina Lario Lago, Kelley Faber, Kathryn Gauthreaux, Ricardo Osorio, Matthew Perkins, Nora Gray, Jill Morris, Andy Liu, Hannah Stockwell, Walter Kukull, Rachael Wilson, Thomas S. Wingo, Nicholas M. Kanaan, Kristen Russ, Donna Wilcock, Sarah A. Biber, Lynn M. Bekris, Thomas K. Karikari   +21 more
wiley   +1 more source

Lipidomics combined with amino acids and their derivatives: Targeted metabolomics analysis for the quality deterioration of coconut water. [PDF]

Curr Res Food Sci
Wang T, Zhang M, Chen W, Chen L, Xie M, Yun YH.   +5 more
europepmc   +1 more source

Integrated Assessment of Lipid Oxidation and Off‐Flavor Formation in Plant Protein Powders

Journal of the American Oil Chemists' Society, Volume 103, Issue 5, Page 371-386, May 2026.
Impact of residual lipids on oxylipin and off‐flavor formation in commercial plant proteins: A detailed analysis of precursor‐product relationships by GC‐FID, LC‐MS/MS, and GC‐MS. ABSTRACT The widespread adoption of plant proteins is hindered by their inherent off‐flavors, often linked to lipid oxidation products.
Fernanda Furlan Goncalves Dias, Wellington da Silva Oliveira, Stanislau Bogusz Junior, Ameer Y. Taha   +3 more
wiley   +1 more source

Oncogenic driver and therapeutic target: Prolactin signalling axis in retroperitoneal sarcoma

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Retroperitoneal sarcoma cells can secrete prolactin into the bloodstream, inducing hyperprolactinaemia, which subsequently triggers metabolic reprogramming, such as glucose metabolism. SOX4 can function as a transcription factor that facilitates PRL transcription.
Fu'an Xie, Lingwei Gu, Kunrong Yang, Shuai Wang, Mengmeng Xiao, Guangting Yan, Quan Zhang, Rubing Liang, Aobo Zhuang, Zhe Xi, Yujia Niu, Yanhua Chen, Xiaogang Xia, Linlin Qu, Bin Zhao, Weibing Li, Ting Wu, Chundong Yu, Chenghua Luo, Houzhao Wang, Lanlan Lian, Wengang Li   +21 more
wiley   +1 more source

Preliminary lipidomics and transcriptomics reveals stage-specific dynamic metabolic patterns from menopause transition to postmenopause. [PDF]

Front Endocrinol (Lausanne)
Zhan Q, Li MM, Chen X, Feng RZ, Ren QL, Du Q.   +5 more
europepmc   +1 more source