Results 31 to 40 of about 1,867,767 (311)

Construction of Eicosatetraenoic Acid Producing Cell Factory by Genetic Engineering of Mucor circinelloides

Fermentation, 2023
Eicosatetraenoic acid (ETA, 20:4, ω-3) is the desaturation product of dihomo-gamma linolenic acid (DGLA, 20:3, ω-6) catalyzed by delta-17 desaturase, which is considered as a healthy product that helps to lower risk of heart diseases.
Chen Wu, Junhuan Yang, Shaoqi Li, Wenyue Shi, Futing Xue, Qing Liu, Tahira Naz, Hassan Mohamed, Yuanda Song   +8 more
doaj   +1 more source

Efficacy and safety of alirocumab in reducing lipids and cardiovascular events.

New England Journal of Medicine, 2015
BACKGROUND Alirocumab, a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9), has been shown to reduce low-density lipoprotein (LDL) cholesterol levels in patients who are receiving statin therapy.
Jennifer G. Robinson, M. Farnier, M. Krempf, J. Bergeron, G. Luc, M. Averna, E. Stroes, G. Langslet, F. Raal, M. El Shahawy, M. Koren, N. Lepor, C. Lorenzato, R. Pordy, U. Chaudhari, J. Kastelein   +15 more
semanticscholar   +1 more source

ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes

Journal of Lipid Research, 2004
High levels of expression of the ATP binding cassette transporter A1 (ABCA1) in the liver and the need to over- or underexpress hepatic ABCA1 to impact plasma HDL levels in mice suggest a major role of the liver in HDL formation and in determining ...
Daisy Sahoo, Timothy C. Trischuk, Teddy Chan, Victor A.B. Drover, Samuel Ho, Giovanna Chimini, Luis B. Agellon, Ricky Agnihotri, Gordon A. Francis, Richard Lehner   +9 more
doaj   +1 more source

Cardiovascular disease risk markers in children under 10 years of age and their relationship with serum concentrations of IGF-1, IGFBP-1, IGFBP-2 and IGFBP-3

Revista de la Facultad de Medicina, 2020
Introduction: Any type of nutritional imbalance experienced during childhood will affect the health of an individual, both in their childhood and their adulthood.
Sorany Vera, Tatiana Figueroa, Luz Helena Aranzalez, Ismena Mockus   +3 more
doaj   +1 more source

Homologous and Heterologous Expression of Delta(12)-Desaturase in Mucor circinelloides Enhanced the Production of Linolenic Acid

Molecules, 2022
Linolenic acid (LA) is gaining more interest within the scientific community. This is because it has a potential medical role in reducing the risk of inflammation, carcinogenesis, atherosclerosis and diabetes and is a valuable nutraceutical for human ...
Junhuan Yang, Xiuwen Wang, Hassan Mohamed, Shaoqi Li, Chen Wu, Wenyue Shi, Futing Xue, Sergio López-García, Yuanda Song   +8 more
doaj   +1 more source

Genetics of Blood Lipids Among ~300,000 Multi-Ethnic Participants of the Million Veteran Program

Nature Genetics, 2018
The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of US military veterans.
D. Klarin, S. Damrauer, Kelly Cho, Yan V. Sun, T. Teslovich, J. Honerlaw, D. Gagnon, S. Duvall, Jin Li, G. Peloso, M. Chaffin, Aeron M. Small, Jie Huang, Hua Tang, J. Lynch, Y. Ho, Dajiang J. Liu, C. Emdin, Alexander Li, J. Huffman, Jennifer S. Lee, P. Natarajan, Rajiv Chowdhury, D. Saleheen, M. Vujković, A. Baras, S. Pyarajan, E. Angelantonio, B. Neale, A. Naheed, A. Khera, J. Danesh, Kyong‐Mi Chang, G. Abecasis, C. Willer, F. Dewey, D. Carey, J. Concato, J. Gaziano, C. O’Donnell, P. Tsao, S. Kathiresan, D. Rader, P. Wilson, T. Assimes, Global Lipids Genetics Consortium, M. Consortium, The Geisinger-Regeneron DiscovEHR Collaboration, the Million Veteran Program   +48 more
semanticscholar   +1 more source

Docosahexaenoic acid (DHA), essentiality and requirements: why and how to provide supplementation

Grasas y Aceites, 2006
Lipids comprize from 50-60% of the structural matter of the brain and docosahexaenoic acid (C22:6, DHA) is the most  important omega-3 long-chain polyunsaturated fatty acid in the brain phospholipids comprizing 25% of the total fatty acids of the grey ...
Alfonso Valenzuela, B. Julio Sanhueza, Susana Nieto   +2 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Serum Lipidome and Metabolome Alterations in Obese Patients Undergoing Targeted Diet and Exercise Interventions: A Marker of Thyroid Function Recovery?

International Journal of Endocrinology
Trial Registration: Chinese Registry of Clinical Trials ...
Changxu Zhou, Heng Wang, Qingtao Yu, Jingxin Xin, Huiqi Chen, Ran Zhang, Qingbo Guan, Shanshan Shao   +7 more
doaj   +1 more source

A plasma circulating miRNAs profile predicts type 2 diabetes mellitus and prediabetes: from the CORDIOPREV study

Experimental and Molecular Medicine, 2018
Metabolic disease: a red flag for diabetes risk Tiny RNA molecules circulating in the blood could give early warning of type 2 diabetes risk. MicroRNAs help regulate the expression of other genes, and recent research has linked irregularities in these ...
Rosa Jiménez-Lucena, Antonio Camargo, Juan Francisco Alcalá-Diaz, Cristina Romero-Baldonado, Raúl Miguel Luque, Ben van Ommen, Javier Delgado-Lista, Jose María Ordovás, Pablo Pérez-Martínez, Oriol Alberto Rangel-Zúñiga, Jose López-Miranda   +10 more
doaj   +1 more source