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Lipocalin-2 as a mediator of neuroimmune communication

Journal of Leukocyte Biology, 2023
Abstract Lipocalin-2, a neutrophil gelatinase-associated lipocalin, is a 25-kDa secreted protein implicated in a broad range of inflammatory diseases affecting the brain and periphery. It is a pleotropic protein expressed by various immune and nonimmune cells throughout the body.
Ruqayya Afridi   +4 more
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Research Progress on Lipocalin-2 in Diabetic Encephalopathy

Neuroscience, 2023
Diabetic encephalopathy is a central nervous complication of diabetes mellitus which is characterized by cognitive impairment and structural and neurochemical abnormalities, which is easily neglected. Lipocalin-2 (LCN2) is a 25 kDa transporter in the lipocalin family that can transport small molecules, including fatty acids, iron, steroids, and ...
Wenjie, Zhang   +2 more
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The role of lipocalin‐2 in liver regeneration

Liver International, 2014
AbstractBackground & AimsVarious immune mediators such as interleukin‐6 (IL‐6) have been implicated in the process of liver regeneration. Lipocalin‐2 (LCN2) has been recently characterized as a prototypic immune mediator produced by various cell types being involved mainly in host defence.
Katrin, Kienzl-Wagner   +7 more
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Lipocalin‐2 is increased in amyotrophic lateral sclerosis

Muscle & Nerve, 2020
AbstractBackgroundThe exact mechanisms underlying neuroinflammation and how they contribute to amyotrophic lateral sclerosis (ALS) pathogenesis remain unclear. One possibility is the secretion of neurotoxic factors, such as lipocalin‐2 (LCN2), that lead to neuronal death.MethodsLCN2 levels were measured in human postmortem tissue using Western blot ...
Tiziana, Petrozziello   +9 more
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Relationships of lipocalin 2 with breast tumorigenesis and metastasis

Journal of Cellular Physiology, 2010
AbstractBreast cancer is one of the most common cancers in women worldwide and accounts for one‐sixth of cancer deaths in the United States. Breast cancer consists of a heterogeneous group of tumours classified into five types, in which the HER2/neu positive and the basal type (most are ER and HER2 negative) have the worst clinical prognosis. In recent
Xiaohong, Leng   +2 more
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Lipocalin 2 as a Membrane-Reorganizing Agent

Science Signaling, 2014
A protein that binds to diverse hydrophobic substrates reorganizes the sperm plasma membrane in preparation for fertilization.
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Requirement of lipocalin 2 for chronic myeloid leukemia

Leukemia & Lymphoma, 2008
The Bcr-Abl oncoprotein causes chronic myeloid leukemia by a mechanism involving its activated tyrosine kinase. BCR-ABL+ mouse hematopoietic cells persistently express and secrete lipocalin 2 by a mechanism that requires the tyrosine kinase of the Bcr-Abl oncoprotein.
Ralph, Arlinghaus, Xiaohong, Leng
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