Results 91 to 100 of about 11,446 (217)

No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer.

PLoS ONE, 2012
NGAL/lipocalin-2 is a siderophore-binding protein that is highly expressed in several cancers. It is suggested to confer a proliferative advantage to cancer cells. Its expression has been correlated with aggressiveness of breast cancer as determined both
Elisabeth P Cramer, Andreas Glenthøj, Mattias Häger, Anna Juncker-Jensen, Lars H Engelholm, Eric Santoni-Rugiu, Leif R Lund, Ole D Laerum, Jack B Cowland, Niels Borregaard   +9 more
doaj   +1 more source

Adaptation of the invasive pest Drosophila suzukii to a specialized nutritional niche

Insect Science, EarlyView.
Unlike most Drosophila larvae that feed on spoiled food, Drosophila suzukii larvae thrive on ripening fruits and consequently face a low‐protein, high‐carbohydrate nutritional challenge. Comparisons of growth among D. suzukii, D. biarmipes, and D. melanogaster larvae across diets with varying protein‐to‐carbohydrate ratios demonstrate that D.
Yan Hou, Ying Zhen
wiley   +1 more source

The Role of Nitric Oxide, Lipocalin-2, and Proinflammatory Cytokines on Proteinuria and Insulin Resistance in Type 2 Diabetes Mellitus Subgroups [PDF]

Chung Hyun Nahm,1 Moon Hee Lee,2 Noriyoshi Fujii,3 Tatsuyoshi Fujii,4 Jong Weon Choi1 1Department of Laboratory Medicine, College of Medicine, Inha University, Incheon, Republic of Korea; 2Department of Internal Medicine, College of Medicine, Inha ...
Lee MH, Nahm CH, Fujii N, Choi JW, Fujii T   +4 more
core  

The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study

Reproductive Biology and Endocrinology, 2010
Background Lipocalin-2 is a novel adipokine that appears to play a role in the development of insulin resistance. Serum lipocalin-2 levels are elevated in obese patients. Obesity and insulin resistance are cardinal characteristics of the polycystic ovary
Kalaitzakis Emmanuil, Delkos Dimitrios, Tsourdi Elena, Kandaraki Eleni A, Koiou Ekaterini, Tziomalos Konstantinos, Panidis Dimitrios, Katsikis Ilias   +7 more
doaj   +1 more source

IgE Sensitization Patterns of Mothers and Their Offspring in the First Five Years of Life The CHILD Study

Allergy, EarlyView.
The spectrum of allergic sensitization in mothers and their offspring was characterized at ages 1–5 years at an extract‐ and molecular level in a North American birth cohort. Fel d 1 was the primary sensitizer in mothers, followed by Phl p 1. Perennial allergen sensitization (Der f 1, Der p 1) was rare at age one but rose sharply by age five.
Mary Asumta Anyango Kodydek, Myrtha E. Reyna, Akash Kothari, Mikhail Monteiro, Jennifer A. Hoang, Kristen Ericka San Diego, Aimee Dubeau, Lisa Hung, Xiaojun Yin, Elinor Simons, Stuart E. Turvey, Piushkumar J. Mandhane, Padmaja Subbarao, Theo J. Moraes, Thomas Eiwegger   +14 more
wiley   +1 more source

Clinical study of plasma lipocalin-2 and endothelial function.

, 2017
Background Recent animal studies suggested that lipocalin-2 plays a key role in the development of hypertension, atherosclerosis and endothelial dysfunction.
B. Cheung, Wang, Y, Tse, HF, K. Lam, H. Tse, Lam, KSL, Cheung, BMY, Y. Wang   +7 more
core   +1 more source

Lipocalin-2 Functions as Inhibitor of Innate Resistance to Mycobacterium tuberculosis

Frontiers in Immunology, 2018
Lipocalin-2 is a constituent of the neutrophil secondary granules and is expressed de novo by macrophages and epithelium in response to inflammation. Lipocalin-2 acts in a bacteriostatic fashion by binding iron-loaded siderophores required for bacterial ...
Sara Louise Dahl, Joshua S. Woodworth, Christian Johann Lerche, Elisabeth Præstekjær Cramer, Pia Rude Nielsen, Claus Moser, Allan Randrup Thomsen, Niels Borregaard, Jack Bernard Cowland, Jack Bernard Cowland   +9 more
doaj   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Lipocalin 2 promotes lung metastasis of murine breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2008
Background Lipocalin 2, an iron binding protein, is abnormally expressed in some malignant human cancers and may play an important role in tumor metastasis. However, the roles of lipocalin 2 in breast cancer formation and metastasis have not been clearly
Mi Wenyi, Xu Liang, Yang Jing, Gu Yuchao, Shi Han, Yu Wengong   +5 more
doaj   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source