Results 21 to 30 of about 29,733,047 (249)

Diminished AdipoR1/APPL1 Interaction Mediates Reduced Cardioprotective Actions of Adiponectin against Myocardial Ischemia/Reperfusion Injury in Type-2 Diabetic Mice

Stem Cells International, 2023
Background. Obesity-related diseases have important implications for the occurrence, severity, and outcome of ischemic heart disease. Patients with obesity, hyperlipidemia, and diabetes mellitus (metabolic syndrome) are at increased risk of heart attack ...
Chao Ren, Wei Yi, Bo Jiang, Erhe Gao, Jiali Liang, Bo Zhang, Zhe Yang, Dezhi Zheng, Yong Zhang   +8 more
doaj   +1 more source

Tissue Distribution of the Lipocalin Alpha-1 Microglobulin in the Developing Human Fetus [PDF]

Journal of Histochemistry & Cytochemistry, 2000
Alpha-1 microglobulin (α 1 m), a lipocalin, is an evolutionarily conserved immunomodulatory plasma protein. In all species studied, α 1 m is synthesized by hepatocytes and catabolized in the renal proximal tubular cells. α 1
L E, Lögdberg, B, Akerström, S, Badve
openaire   +2 more sources

Colorimetric Diagnostic Capillary Enabled by Size Sieving in a Porous Hydrogel

Biosensors, 2020
Handy and disposable point-of-care diagnostics facilitate the early screening of severe diseases in resource-limited areas. To address urgent needs in inconvenient sites, a simple colorimetric diagnostic device equipped with a capillary tube with porous ...
John Mello Camille C. Guzman, Sheng-Min Hsu, Han-Sheng Chuang   +2 more
doaj   +1 more source

DRP1 induces neuroinflammation via transcriptional regulation of NF-ĸB. [PDF]

Nature Communications
Neuroinflammation is a major pathogenic mechanism underlying neurodegenerative diseases. Understanding how neuroinflammation is regulated is critical to therapeutic development.
Yanhao Lai, Rebecca Z. Fan, Harry J. Brown, Said S. Salehe, Ethan K. Tieu, Kim Tieu   +5 more
doaj   +2 more sources

High-Intensity Interval Training Improves Lipocalin-2 and Omentin-1 Levels in Men with Obesity [PDF]

International Journal of Sports Medicine, 2021
Abstract Objectives: We investigated the effects of 12 weeks of high-intensity interval training (HIIT) on selected circulating adipokines and other cardiovascular diseases (CVD) risks factors in males with obesity. Methods: Thirty males with obesity were randomly assigned to HIIT and control groups.
Atashak, Sirvan, Stannard, Stephen R., Daraei, Ali, Soltani, Mohammad, Saeidi, Ayoub, Moradi, Fatah, Laher, Ismail, Hackney, Anthony C., Zouhal, Hassane   +8 more
openaire   +3 more sources

Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension

Arquivos de Neuro-Psiquiatria, 2022
Background Idiopathic intracranial hypertension (IIH) is characterized by increased cerebrospinal fluid (CSF) pressure of unknown cause. It has been suggested that the inflammatory process plays a role in the pathophysiology of the disease.
Ahmet Dündar, Adalet Arıkanoğlu, Hasan Hüseyin Özdemir, Hamza Aslanhan, Mehmet Uğur Çevik   +4 more
doaj   +1 more source

Mammalian derived lipocalin and secretoglobin respiratory allergens strongly bind ligands with potentially immune modulating properties

Frontiers in Allergy, 2022
Allergens from furry animals frequently cause sensitization and respiratory allergic diseases. Most relevant mammalian respiratory allergens belong either to the protein family of lipocalins or secretoglobins.
Bente Janssen-Weets, Bente Janssen-Weets, Frédéric Kerff, Kyra Swiontek, Stéphanie Kler, Rebecca Czolk, Rebecca Czolk, Dominique Revets, Annette Kuehn, Carsten Bindslev-Jensen, Markus Ollert, Markus Ollert, Christiane Hilger   +12 more
doaj   +1 more source

Interaction of uteroglobin with lipocalin-1 receptor suppresses cancer cell motility and invasion [PDF]

Gene, 2006
Cellular migration and invasion are critical for important biological processes including cancer metastasis. We previously reported that uteroglobin (UG), a multifunctional secreted protein, binds to several cell types inhibiting migration and invasion [G.C. Kundu, A.K. Z. Zhang Mandal, G. Mantile-Selvaggi, A.B.
Zhang, Zhongjian, Kim, Sung-Jo, Chowdhury, Bhabadeb, Wang, Jingya, Lee, Yi-Ching, Tsai, Pei-Chih, Choi, Moonsuk, Mukherjee, Anil B.   +7 more
openaire   +2 more sources

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Diagnostic and prognostic performance of urinary neutrophil gelatinase‐associated lipocalin in patients with cirrhosis and acute kidney injury

Hepatology, EarlyView., 2022
Diagnostic and prognostic ability of urinary NGAL in patients with cirrhosis and AKI. Abstract Background and Aims Acute kidney injury (AKI) commonly occurs in patients with decompensated cirrhosis. Urinary neutrophil gelatinase–associated lipocalin (uNGAL) could help discriminate between different etiologies of AKI.
Carmine Gambino, Salvatore Piano, Matteo Stenico, Marta Tonon, Alessandra Brocca, Valeria Calvino, Simone Incicco, Nicola Zeni, Roberta Gagliardi, Chiara Cosma, Martina Zaninotto, Patrizia Burra, Umberto Cillo, Daniela Basso, Paolo Angeli   +14 more
wiley   +1 more source