Results 101 to 110 of about 39,706 (298)

Adverse Outcomes and Associated Factors Among Children and Youths With Diabetes Mellitus in East Africa: A Systematic Review and Meta‐Analysis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To identify adverse outcomes and factors associated with diabetes mellitus among children and youths in East Africa. Design This review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines.
Chalie Marew Tiruneh, Marilyn Cruickshank, Muhammad Chutiyami, Lin Perry   +3 more
wiley   +1 more source

Acquired Lipodystrophy Associated With Nivolumab in a Patient With Advanced Renal Cell Carcinoma.

Journal of Clinical Endocrinology and Metabolism, 2019
CONTEXT Lipodystrophy syndromes are rare disorders characterized by the selective loss of adipose tissue. We aimed to report a case of acquired generalized lipodystrophy possibly associated with nivolumab.
Camila Kruschewsky Falcão, Marina Campos Simoes Cabral, J. M. Mota, Samia T Arbache, A. D. Costa-Riquetto, D. Q. Muniz, J. Cury-Martins, M. Almeida, Priscilla Cukier Kaczemorska, M. Nery, M. Teles   +10 more
semanticscholar   +1 more source

The Trust‐Link Relational Transition Model: A Unitary Caring Framework for Youth With HIV Transitioning to Adult Healthcare

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To develop a conceptual model integrating Robinson's Theory of Trust and Watson's Caritas Processes to guide trust‐building approaches and caring practices that support adolescents and young adults with HIV during the healthcare transition from paediatric to adult care.
Emily Anne Barr, Sara Horton‐Deutsch
wiley   +1 more source

Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy

Journal of Clinical Investigation, 2018
BACKGROUND. Recombinant leptin (metreleptin) ameliorates hyperphagia and metabolic abnormalities in leptin-deficient humans with lipodystrophy. We aimed to determine whether metreleptin improves glucose and lipid metabolism in humans when food intake is ...
Rebecca J Brown, Areli Valencia, M. Startzell, E. Cochran, Peter J. Walter, H. Martin Garraffo, H. Cai, A. Gharib, R. Ouwerkerk, Amber B Courville, Shanna B. Bernstein, R. Brychta, Kong Y Chen, M. Walter, S. Auh, P. Gorden   +15 more
semanticscholar   +1 more source

Identification of A Novel Mutation of SHORT Syndrome: A Case Report

Clinical Case Reports, Volume 13, Issue 9, September 2025.
ABSTRACT SHORT syndrome is a rare inherited disease with 34 identified pathogenic or likely pathogenic PIK3R1 mutations. The genotype–phenotype relationship remains inconsistent. Our case presents the first novel duplication that affects up to 25 nucleotides and truncates the PI3K protein, contributing valuable data to genetic understanding and ...
Quynh Thi Vu Huynh, Tuong Trong Luong, Ho Tran Ban, Van Tran   +3 more
wiley   +1 more source

Genotype-stratified treatment for monogenic insulin resistance: a systematic review

Communications Medicine, 2023
Background Monogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of interventions in monogenic IR, stratified by genetic aetiology.
Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, ADA/EASD PMDI, Rebecca J. Brown   +4 more
doaj   +1 more source

Causes of death in patients with Berardinelli-Seip congenital generalized lipodystrophy

PLoS ONE, 2018
Introduction Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a rare autosomal recessive disease that affects the development of adipocytes and leads to an inability to store fat in adipocytes. This study aimed to evaluate the life expectancy and the
J. G. Lima, L. H. Nóbrega, N. N. Lima, M. C. F. Dos Santos, P. Silva, M. F. Baracho, Debora Nobrega Lima, Julliane Tamara Araújo de Melo Campos, L. C. Ferreira, F. P. Freire Neto, C. Mendes-Aguiar, S. Jeronimo   +11 more
semanticscholar   +1 more source

Polymorphisms of pyrimidine pathway enzymes encoding genes and HLA-B*4001 carriage in stavudine-associated lipodystrophy in HIV-infected patients [PDF]

, 2013
: To assess in a cohort of Caucasian patients exposed to stavudine (d4T) the association of polymorphisms in pyrimidine pathway enzymes and HLA-B*4001 carriage with HIV lipodystrophy syndrome (HALS).
Mateo García, Mª Gracia, Universitat Autònoma de Barcelona. Departament de Medicina, Universitat Autònoma de Barcelona. Facultat de Medicina   +2 more
core   +1 more source

Functional study of Phaeodactylum tricornutum Seipin highlights specificities of lipid droplets biogenesis in diatoms

New Phytologist, Volume 247, Issue 5, Page 2245-2269, September 2025.
Summary Diatoms are a major phylum of microalgae, playing crucial ecological roles. They derive from secondary endosymbiosis, leading to a complex intracellular architecture. Their ability to store oil in lipid droplets (LDs) upon unfavourable conditions has raised interest for applications, in particular biofuels, yet Lipid Droplet (LD) biogenesis ...
Damien Le Moigne, Marta Carletti, Chems Amari, Rachel Bonnarde, Fabien Richard, Catherine Albrieux, Mégane Mahieu, Matteo Arrighi, Grégory Si‐Larbi, Pierre‐Henri Jouneau, Valérie Gros, Mathilde Louwagie, Sylvaine Roy, Yangmin Gong, Yufang Pan, Hanhua Hu, Olivier Bastien, Juliette Jouhet, Alberto Amato, Eric Maréchal, Juliette Salvaing   +20 more
wiley   +1 more source

Estimating the prevalence of generalized and partial lipodystrophy: findings and challenges

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2017
Background Lipodystrophy (LD; non-human immunodeficiency virus [HIV]-associated) syndromes are a rare body of disorders for which true prevalence is unknown.
E. Chiquette, E. Oral, A. Garg, D. Araújo-Vilar, Praveen Dhankhar   +4 more
semanticscholar   +1 more source